Gene manipulation: the possibility of inhibiting myostatin for muscle hypertrophy

Abstract

Objective: Recognize the possibility of inhibiting myostatin through genetic editing and the possible benefits caused by this alteration, in the creation of biophysically modified human beings. Literature review: Genetic engineering is developing techniques that seek to improve genomic characteristics, such as muscular endurance and physical strength. These characteristics are highly conditioned by myostatin, a protein linked to the process of skeletal muscle atrophy, and to various diseases, such as AIDS and heart failure. Therefore, studies were analyzed in which there were inhibitions in the expression of myostatin, in bovines and mice, leading to significant muscle gain. After analysis, the genes transcribing the protein were decoded in mice and in the human species, leading to the perception of strong genetic similarities between the groups, suggesting the possibility of muscle and endurance gains at high levels through gene editing in humans, as well as attested in animal species. Final considerations: Despite being a study in development, it is necessary to understand the benefits and harms related to gene therapy, considering the possibilities of its applicability in the gain of resistance and muscle mass in humans, which will represent an undeniable advance for the current scientific-technological scenario.