Keywords
Immunonutrition
Nutrients
Nutritional Therapy
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Abstract
Objective: To analyze the effects of immunonutrition in supporting treatment and its benefits in cancer patients. Bibliographic review: Glutamine helps to improve the immune system as it is the preferred source of fuel for enterocytes, lymphocytes and macrophages. And because it is important for metabolic processes, including protein synthesis, it helps to recover and increase muscle mass. Arginine, on the other hand, positively influences the tissue regeneration process, making the healing process even more efficient, with a lower rate of complications and postoperative fistulas. Omega-3 acts by suppressing the transcription of pro-inflammatory genes, stimulating inflammatory mediator pathways, slowing tumor growth. Final considerations: Immunonutrition plays a significant role in the nutritional support of patients, being widely adopted due to its ability to contribute to the improvement of the clinical status of individuals. This manifest itself through the modulation of not only immunological, but also metabolic and inflammatory processes. In addition, immunonutrition is particularly valuable in situations where the nutritional status of patients is depleted, providing a diverse range of benefits during the treatment of various neoplasms.
References
ABRAHÃO SAB e MACHADO EC. Suplementação de Glutamina no Tratamento de Pacientes com Câncer: uma revisão bibliográfica. 2014; 41(2):215-22.
ARENDS J, et al. Diretriz BRASPEN de terapia nutricional no paciente com câncer. BRASPEN Journal, 2019; 341): 11-48.
BOLIGON CS e HUTH A. O Impacto Do Uso De Glutamina Em Pacientes Com Tumores De Cabeça E Pescoço Em Tratamento Radioterápico E Quimioterápico. Rev. Bras. Cancerol. 2011, 57, 31-38.
BRAY F, et al. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA: a cancer journal for clinicians, 68(6), 394–424.
CALDER PC. Nutrition, immunity and COVID-19. BMJ Nutrition, Prevention & Health, 2020; 3(1), 74-92.
CHÁIDEZ YLB, et al. Effect of parenteral glutamine in patients with gastrointestinal cancer undergoing surgery. Nutrición hospitalaria, 2019; 36(1), 5-12.
CORREIA MLS, et al. Ômega-3 como Composto Bioativo Adjuvante à Terapia Nutricional da Caquexia Oncológica. Revista Referência em Saúde da Faculdade Estácio de Sá de Goiás, 2020;1(3):145-150.
CUPPARI L. Nutrição clínica no adulto. 4. ed. São Paulo: Manole, 2019.
DA SILVA L, et al. Suplementação de glutamina e seu benefício no tratamento do câncer: uma revisão integrativa. Revista Brasileira de Desenvolvimento, 2023; 9 (3), 9456–9475.
FALCONER JS, et al. Nutritional Support and Clinical Outcomes in Malnourished Patients with Cancer. Clinical Nutrition ESPEN, 2020; 39, 39-48.
FERREIRA C, et al. Suplementação com arginina na terapia nutricional de pacientes com câncer de cabeça e pescoço. Revista Eletrônica Acervo Saúde, 2019;27:e760.
GOMEZ M, et al. Resposta Imunológica na Erradicação do Câncer. Revista de Medicina Oncológica, 2021;15(1)20-35.
HÉBUTERNE X, et al. Prevalence of Malnutrition and Current Use of Nutrition Support in Patients with Cancer. Journal of parenteral and Enteral Nutrition, 2020; 44(4), 647-655.
HORIE LM, et al. Diretriz BRASPEN de terapia nutricional no paciente com câncer. BRASPEN Journal, 2019; 34(1): 2-32.
JABŁOŃSKA B e MROWIEC S. The Role of Immunonutrition in Patients Undergoing Pancreaticoduodenectomy. Nutrients. 2020; 12(9):2547.
LÓPEZ E, et al. The Effect of Amino Acids on Wound Healing: A Systematic Review and Meta-Analysis on Arginine and Glutamine. Nutrients, 2021; 13(8): 2498.
MACHADO G, et al. Nutracêuticos: aspectos legais e científicos. Revista Eletrônica de Farmácia, 2019; 16 (E).
MIRANDA M, et al. Glutamina na Prevenção e Tratamento da Mucosite em Pacientes Adultos Oncológicos: Uma Revisão Sistemática da Literatura. Revista brasileira de Cancerologia, 2015;61(3). 277,285.
NABAVI SF, et al. Omega-3 polyunsaturated fatty acids and cancer: lessons learned from clinical trials. Cancer Metastasis Rev. 2015; 34(3):359–80.
OSLAND E, et al. Effect of timing of pharmaconutrition (immunonutrition) administration on outcomes of elective surgery for gastrointestinal malignancies: a systematic review and meta-analysis. JPEN J Parenter Enteral Nutr. 2014; 38(1):53-69.
ROSSI FE, et al. The Role of Immunonutrition in the Postoperative Healing Process of Gastrointestinal Cancer: A Narrative Review. Nutricion Hospitalaria, 2021; 38(3), 697-705.
SIDDIQUI NU, et al. Immunonutrition in cancer patients: A systematic review and meta-analysis. Clinical Nutrition, 2020; 39(10), 2943-2949.
TAN SE, et al. Effects of Immunonutrition in Head and Neck Cancer Patients Undergoing Cancer Treatment - A Systematic Review. Front Nutr. 2022; 9:821924.
VOSS AC, et al. Immunonutrition for Athletes: A Systematic Review. International Journal of Sport Nutrition and Exercise Metabolism, 2021 31(4), 335-346.
WAITZBERG DL. Nutrição oral, enteral e parenteral na pratica clínica. 5. Ed. São Paulo: Atheneu; 2017.
WEIMANN A, et al. ESPEN guideline: Clinical nutrition in surgery. Clin Nutr. 2017; 36(3):623-50.
WISCHMEYER PE, et al. Rethinking Nutritional Support in Patients with Coronavirus Disease-2019. JPEN Journal of Parenteral and Enteral Nutrition, 2020; 44(7), 1156-1157.
ZHANG L, et al. Effect of preoperative immunonutrition on postoperative complications and immunologic function in gastric cancer patients following radical gastrectomy. Cancer Management and Research, 2021; 13, 4055-4064.