Keywords
Gastrointestinal microbiome
Autoimmune diseases
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Abstract
Objective: To elucidate the repercussions that alterations in the intestinal microbiota have on the pathophysiological processes of autoimmune diseases. Literature review: The microbiota is the set of microorganisms that live in the human intestines, representing trillions of bacteria, a number 10 times greater than the amount of human cells that make up the human body. This entity establishes complex relationships with the human organism, either by producing various substances, competing for resources against potential pathogens, or interacting with the immune system. In this context, alterations in this microbiota can cause imbalances in these complex interactions, potentially harming the organism, as demonstrated in this article against the backdrop of diseases such as type 1 diabetes mellitus, rheumatoid arthritis, multiple sclerosis, systemic lupus erythematosus and celiac disease. Final considerations: Investigating and better understanding these relationships between microbiota and autoimmune diseases opens the way for new therapeutic and preventive strategies, potentially improving the quality of life of patients affected by these complex conditions.
References
ABBAS AK, et al. Basic Immunology: Functions and Disorders of the Immune System. Elsevier, 2018; 22.
AN J, et al. The role of intestinal mucosal barrier in autoimmune disease: A potential target. Frontiers in Immunology, 2022; 13: 871713.
BÄCKHED F, et al. Dynamics and stabilization of the human gut microbiome during the first year of life. Cell host & microbe, 2015; 17(6): 852.
BELKAID Y e HAND TW. Role of the Microbiota in immunity and inflammation. Cell, 2014; 157(1): 121–141.
BRUSCA SB, et al. Microbiome and mucosal inflammation as extra-articular triggers for rheumatoid arthritis and autoimmunity. Current Opinion in Rheumatology, 2014; 26(1): 101–107.
CHANG C e LIN H. Dysbiosis in gastrointestinal disorders. Best practice & research. Clinical gastroenterology, 2016; 30(1): 3–15.
CHEN J e VITETTA L. Intestinal dysbiosis in celiac disease: Decreased butyrate production may facilitate the onset of the disease. Proceedings of the National Academy of Sciences of the United States of America, 2021; 118(41): 2113655118.
CHRISTOVICH A e LUO XM. Gut Microbiota, leaky gut, and autoimmune diseases. Frontiers in Immunology, 2022; 13: 946248.
CRISPIM J. Sistema Nervoso e Doenças Autoimunes: uma revisão. Revista Inova Saúde, 2024; 14(5): 2117–2460.
DE LUCA F e SHOENFELD Y. The microbiome in autoimmune diseases. Clinical and Experimental Immunology, 2019; 195(1): 74–85.
DE OLIVEIRA GLV, et al. Intestinal dysbiosis and probiotic applications in autoimmune diseases. Immunology, 2017; 152: 1-12.
JIAO Y, et al. Crosstalk between gut Microbiota and innate immunity and its implication in autoimmune diseases. Frontiers in Immunology, 2020; 11: 282.
JOHNSON BM, et al. Gut microbiota differently contributes to intestinal immune phenotype and systemic autoimmune progression in female and male lupus-prone mice. Journal of Autoimmunity, 2020; 108(102420): 102420.
KIM JW, et al. Recent advances in our understanding of the link between the intestinal Microbiota and systemic lupus erythematosus. International journal of molecular sciences, 2019; 20(19): 4871.
KINASHI Y e HASE K. Partners in leaky gut syndrome: Intestinal dysbiosis and autoimmunity. Frontiers in immunology, 2021; 12: 673708.
KNIP M e SILJANDER H. The role of the intestinal microbiota in type 1 diabetes mellitus. Nature Reviews. Endocrinology, 2016; 12(3): 154–167.
LEONARD MM, et al. Microbiome signatures of progression toward celiac disease onset in at-risk children in a longitudinal prospective cohort study. Proceedings of the National Academy of Sciences of the United States of America, 2021; 118(29): 2020322118.
LEVY M, et al. Dysbiosis and the immune system. Nature Reviews. Immunology, 2017; 17(4): 219–232.
LOPEZ RN, et al. Differences in gut microbiome profile between healthy children and children with inflammatory bowel disease and/or autoimmune liver disease: A case-control study. Pathogens, 2023; 12(4): 585.
MOUSA WK, et al. Microbial dysbiosis in the gut drives systemic autoimmune diseases. Frontiers in immunology, 2022; 13: 906258.
MIYAUCHI E, et al. The impact of the gut microbiome on extra-intestinal autoimmune diseases. Nature Reviews Immunology, 2023; 23(1): 9–23.
OPAZO MC, et al. Intestinal Microbiota influences non-intestinal related autoimmune diseases. Frontiers in microbiology, 2018; 9: 432.
PELÁEZ JP, et al. Relación de la microbiota intestinal con enfermedades autoinmunes. Revista Vive, 2023; 6 (16): 142–153.
ROGERS GB. Germs and joints: the contribution of the human microbiome to rheumatoid arthritis. Nature medicine, 2015; 21(8): 839–841.
VATANEN T, et al. Variation in microbiome LPS immunogenicity contributes to autoimmunity in humans. Cell, 2016; 165(4): 1551.
WU WJH, et al. Intestinal microbes in autoimmune and inflammatory disease. Frontiers in Immunology, 2020; 11: 597966.
WU X, et al. Gastrointestinal microbiome and gluten in celiac disease. Annals of medicine, 2021; 53(1): 1797–1805.