Abstract
Objective: Analyze how different dietary patterns influence the phases of crisis and remission in Crohn's disease. Literature review: Crohn's disease (CD) is a chronic inflammatory condition affecting the gastrointestinal tract, characterized by phases of crisis and remission. In this context, diet plays an essential role in managing the disease, directly impacting the gut microbiota and inflammatory response. During crises, a balanced diet can help mitigate symptoms and prevent the worsening of inflammation, while in remission, an adequate diet can promote a healthy microbial environment, reducing the risk of relapse. Final considerations: Diet is a fundamental component in the management of Crohn's Disease. Specific, well-balanced diets, adapted to the needs of each phase, not only relieve symptoms during flares, but also strengthen the body to prolong periods of remission. The inclusion of fibre and anti-inflammatory foods is a promising strategy for stabilizing the intestinal microbiota and reducing inflammation, promoting a better quality of life for CD patients.
References
AVIELLO G, et al.ROS in gastrointestinal inflammation: Rescue or Sabotage? British Journal of Pharmacology, 2017; 174(12): 1704–1718.
BAÊTA OM, et al. Doença de Crohn - uma revisão abrangente sobre a epidemiologia, fisiopatologia e patogênese, fatores de risco, diagnóstico clínico, diagnóstico imagiológico, manifestações extra intestinais, tratamento, nutrição e dieta. Brazilian Journal of Health Review, 2023; 6(4): 17438–17454.
BARBERIO B, et al. Prevalence of symptoms of anxiety and depression in patients with inflammatory bowel disease: a systematic review and meta-analysis. The Lancet Gastroenterology & Hepatology, 2021; 6(5): 359-370.
BASSON A, et al.Nutrition management in the adult patient with Crohn’s disease. South African J Clin Nutr, 2012; 25(4): 164–72.
CASTRO AM, et al.Parâmetros gerais da Doença de Crohn: fisiopatologia, fatores de desenvolvimento e incidência. JNT Facit Business and Technology Journal, 2023;1:3-18
COSTESCU S, et al. Does Magnesium Provide a Protective Effect in Crohn’s Disease Remission? A Systematic Review of the Literature. Nutrients, 2024; 16(1662).
DANIEL H, et al. The role of diet in the modulation of the gut microbiota. Nature Reviews Gastroenterology & Hepatology, 2019; 16(1): 1-15.
GEDIIB, et al. Grupo de Estudo da Doença Inflamatória Intestinal do Brasil. Atualização em Doenças Inflamatória Intestinais: Conectando a ciência à prática diária, 2019; p.172.
GHOSH S, et al. Dietary interventions in inflammatory bowel disease: A review. Journal of Gastroenterology and Hepatology, 2020; 35(5): 789-797.
GOUVEIA EC e ÁVILA LA. Aspectos emocionais associados a disfunções gastroenterológicas. Psicologia em Estudo, 2010; 15(2): 265-273.
GU P e FEAGINS LA. Diet in the pathogenesis and management of Crohn’s disease. Gastroenterology Clinics of North America, 2022; 51: 319-335.
GUTIERREZ A, et al. Dietary fibers and their role in the modulation of gut microbiota. Nutrients, 2020; 12(5): 1-15.
HENDY P e HART A. A Review of Crohn’s Disease. Eur Med J, 2013; 1: 116–23.
HENRY CJ, et al. Nutrition education and dietary interventions for patients with inflammatory bowel disease. Journal of Crohn's and Colitis, 2021; 15(1): 1-10.
INSFRAN LFL,et al. Contribuição genética para o entendimento da fisiopatologia da doença de Crohn / Genetic contribution to understanding the pathophysiology of Crohn’s disease. Brazilian Journal of Health Review, 2022; 5(2): 6265–6278
KAMMERMEIER J, et al. Management of Crohn’s disease. Arch Dis Child, 2015; 475–80.
MALIK A, et al. Gut microbiota and obesity: a review. Journal of Clinical Gastroenterology, 2018; 52(1): 1-10.
SANDERS ME, et al. Probiotics and prebiotics in intestinal health and disease: from biology to the clinic. Nature Reviews Gastroenterology & Hepatology, 2019; 16(1): 1-15.
SANTOS JE, et al. Manifestações clínicas e dermatológicas da doença de Crohn em pacientes imunossuprimidos, 2023.
SARLO RS, et al.Compreendendo a vivência do paciente portador da doença de Crohn. Acta Paul. Enferm., 2008; 21(4): 629-635.
SZCZUBEŁEK M, et al. Effectiveness of Crohn’s Disease Exclusion Diet for Induction of Remission in Crohn’s Disease Adult Patients. Nutrients, 2021; 13(4112).
VADLAPUDI SS, et al. Dietary interventions in Crohn’s disease: A simple solution to refractory disease. Indian Journal of Gastroenterology, 2024; 43(1): 18-21.
WĘDRYCHOWICZ A, et al. Advances in nutritional therapy in inflammatory bowel diseases: Review. World J Gastroenterol, 2016; 22(3): 1045–66.
YAMAMOTO FJK, et al. Diagnóstico y tratamiento de la enfermedad inflamatoria intestinal: Primer Consenso Latinoamericano de la Pan American Crohn’s and Colitis Organisation. Rev Gastroenterol México, 2016.
ZALTMAN C, et al. As Doenças Inflamatórias Intestinais na Atualidade Brasileira. Office Publicações Científicas Ltda, 2018.
ZHANG JL, et al. The effect of solid food diet therapies on the induction and maintenance of remission in Crohn’s disease: a systematic review. BMC Gastroenterology, 2024; 24(250).
