Keywords
Oncological treatment
Salivary glands and laser therapy
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Abstract
Objective: To describe the use of low-level laser therapy (LLLT) in the treatment of radiation-induced xerostomia, highlighting its efficacy and importance in managing the condition and improving patients' quality of life. Methods: This study is an integrative literature review with qualitative analysis, where searches were conducted based on articles published between 2020 and 2024 in the PubMed (MEDLINE), Scielo, and Google Scholar databases, using descriptors such as "xerostomia", "oncological treatment", "salivary glands", "laser therapy", among others. Results: Xerostomia is a common condition in patients undergoing radiation therapy in the head and neck region. LLLT is an effective therapeutic alternative for alleviating symptoms, improving salivary flow, and promoting cellular regeneration. The dosage, duration, and frequency of sessions are essential factors for the success of treatment. Final considerations: LLLT is a promising alternative for treating post-radiation xerostomia, improving patients' quality of life. However, it is essential to follow specific application protocols and conduct further studies to establish precise parameters. Healthcare professionals, especially dentists, play a fundamental role in managing xerostomia.
References
ALBUQUERQUE RF. Eficácia da fotobiomodulação extraoral na prevenção do hipofluxo salivar em pacientes tratados com radioterapia para câncer de cabeça e pescoço: ensaio clínico randomizado duplo-cego. Dissertação (Mestrado em Odontologia) – Universidade Federal de Pernambuco, Recife, 2020.
ALSOGHIER A, et al. Tratamento da hipossalivação induzida por radioterapia usando terapia de fotobiomodulação: uma série de casos. Lasers in Medical Science, 2025; 40: 25.
BASTOS GLL, et al. Efeitos da quimioterapia e da radioterapia na saúde bucal. Revista Ibero-Americana de Humanidades, Ciências e Educação, 2024; 10(10): 5363–5372.
CHAO KS, et al. A prospective study of salivary function sparing in patients with head-and-neck cancers receiving intensity-modulated or three-dimensional radiation therapy: initial results. International Journal of Radiation Oncology Biology Physics, 2001; 49: 907–916.
CHENG VST, et al. The function of the parotid gland following radiation therapy for head and neck cancer. International Journal of Radiation Oncology Biology Physics, 1981; 7: 253–258.
FAJARDO LF, et al. Salivary glands. In: Radiation pathology. Minnesota: Oxford University Press, 2001; 265–270.
GONZÁLEZ-ARRIAGADA WA, et al. Efficacy of low-level laser therapy as an auxiliary tool for management of acute side effects of head and neck radiotherapy. Journal of Cosmetic Laser Therapy, 2018; 20: 117–122.
HEISKANEN V, et al. Photobiomodulation Therapy for Cancer Treatment-Related Salivary Gland Dysfunction: A Systematic Review. Photobiomodulation, Photomedicine, and Laser Surgery, 2020; 38(6): 340–347.
LOPES CO, et al. Prevenção da xerostomia e da mucosite oral induzidas por radioterapia com uso do laser de baixa potência. Radiologia Brasileira, 2006; 39(2): 123–128.
MANIÇOBA AKL, et al. Acompanhamento odontológico de paciente oncológico em tratamento quimioterápico. Revista de Odontologia da UNESP, 2022; 51.
MOSANNEN MOZAFFARI P, et al. Evaluation of the effect of photobiomodulation on radiation-induced xerostomia in head and neck cancer patients: a randomized clinical trial. *Journal of Lasers in Medical Sciences, 2024; 15: 4.
PALMA LF, et al. Impact of low-level laser therapy on hyposalivation, salivary pH, and quality of life in head and neck cancer patients post-radiotherapy. Lasers in Medical Science, 2017; 32: 827–832.
PATEL AS, et al. The effect of photobiomodulation on chemoradiation-related xerostomia: a clinical case. Journal of Laser Dentistry, 2022; 26(1).
RENTARO GASLC, et al. Immediate effects of photobiomodulation on saliva production. CoDAS, 2024; 36: 3.
SCHEPANSKI N, et al. Evaluation of photobiomodulation therapy (PBMT) on salivary flow and composition in head and neck cancer patients undergoing radiation therapy. Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, 2024; 137(3): 253–263.
SEABRA SB, et al. Laserterapia no controle da xerostomia após radioterapia na região da cabeça e do pescoço. Revista Portuguesa de Estomatologia, Medicina Dentária e Cirurgia Maxilofacial, 2021; 62(2).
SEMBA SE, et al. The head and neck radiotherapy patient: Part 1 – oral manifestations of radiation therapy. Compendium of Continuing Education in Dentistry, 1994; 15: 252–260.
SILVA SC, et al. Principais manifestações bucais em pacientes submetidos à quimioterapia: abordagem e tratamento odontológico. Revista Multidisciplinar do Nordeste Mineiro, 2023; 1: 1.