Keywords
Gut
Microbiota
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Abstract
Objective: To investigate the relationship between intestinal dysbiosis and atopic dermatitis (AD), highlighting the role of the gut-skin axis in intensifying the clinical manifestations of the disease. Literature review: AD is a chronic inflammatory skin condition that primarily affects children and is associated with genetic, immunological, environmental, and emotional factors. Alterations in the gut microbiota influence the immune response, promoting an imbalance between Th1/Th2 lymphocytes and impairing the skin barrier. Mutations in the filaggrin gene, reduced ceramides and claudins, as well as environmental exposures and modern lifestyle habits, are identified as aggravating factors. The reduced production of short-chain fatty acids (SCFAs) in individuals with dysbiosis may increase intestinal permeability and trigger systemic inflammatory responses. Final considerations: Understanding this relationship may assist in developing integrative therapies involving microbiota modulation as a complementary approach to the treatment of AD. Moreover, considering emotional and environmental factors in the management of AD is essential to improve patients' quality of life and prevent recurrences.
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