Keywords
Obesity management
GLP-1 receptor agonists
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Abstract
Objective: To evaluate the efficacy and safety of using GLP-1 receptor agonists (GLP-1RAs) in overweight/obese women planning pregnancy. Methods: This is a systematic review, with randomized clinical trials (RCTs) obtained from the National Library of Medicine, Virtual Health Library, and Ovid Cochrane Central Register of Controlled Trials databases. The studies were screened using Rayyan software and assessed according to the Jadad et al. (1996) scale. Results: The RCTs included in the sample addressed metabolic and reproductive outcomes related to the use of GLP-1RAs in overweight/obese women prior to conception. Only three studies discussed obstetric adverse reactions. In these studies, GLP-1RAs were described as safe and associated with a lower frequency of adverse events. Furthermore, the use of GLP-1 receptor agonists demonstrated greater efficacy when combined with other medications aimed at improving metabolic and reproductive functions in this population.Final considerations: Despite the therapeutic variety and the undeniable metabolic and reproductive benefits of GLP-1RA therapy in overweight/obese women planning pregnancy, the number of RCTs addressing obstetric safety outcomes is limited, and most have small sample sizes, maintaining the impasse in implementing this therapy.
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