Abstract
This study sought to deepen, through a systematic bibliographic review, about psychodermatology, which is the union of Dermatology and Psychiatry, in order to end a vicious cycle in which the existence of psychological disorders generate skin changes and dermatological manifestations are capable of leading to psychic changes. In the meantime, after a stressful situation, by means of different mechanisms, the release of several neuropeptides and neurotrophins is triggered, which have pro-inflammatory effects, mainly through the activation of mast cells, leading to neurogenic inflammation. Therefore, with the appearance of dermatoses, a self-confidence is compromised, which can cause psychological distress, since physical appearance is the first impression in human contact and is an important form of communication. Given its importance and psychosocial impact, a therapeutic approach must be multidisciplinary, involving primary care physicians, dermatologists, psychiatrists and psychologists, in order to enable the treatment of psychodermatoses in their total complexity.