Abstract
Objective: This article sought to discuss the relationship between psoriasis and depression, aiming to present information that correlates how the worsening of psoriasis can intensify depressive symptoms, as well as the increase in depressive symptoms can lead to the progression of psychodermatosis. Bibliographic review: It has been shown that antidepressant treatment contributes to the management of dermatological pathology, as well as Tumor Necrosis Factor (TNF) inhibitors, used in the treatment of psoriasis, collaborate with the improvement of depressive symptoms, since both are related to the elevated release of pro-inflammatory cytokines. However, the exact mechanism of how inflammation intervenes in both pathologies is not yet fully elucidated. Final considerations: Therefore, multidimensional treatment is necessary, taking into account the psychological, social and physical well-being aspects, since psoriasis has no cure and the treatment of depression would minimize the adverse effects of this dermatosis.