Abstract
This article aims to report of a case of gangrenous pyoderma responsive to rescue therapy with infliximab. Female patient, 42 years old, with Crohn's disease using Mesalazine. He evolved with arthralgia in large joints, when Azathioprine was prescribed, and since then he has had phlogistic signs in tissues of both forearms and mucosanguinous diarrhea. He required hospitalization, where antibiotic therapy and then intravenous corticotherapy prevailed, with no improvement in the clinical picture. At the end of the second week of treatment, the cutaneous lesions transformed quite characteristic of gangrenous pyoderma and still had diarrhea. It was biological therapy with infliximab, with the disappearance of the articular condition, regularization of the intestinal habit and healing of skin ulcers, right after the first infusion. The response therapy with infliximab was effective for a rapid clinical response of the patient with acute Crohn's disease and healing of gangrenous pyoderma.