Abstract
Objective: Describe about the tumor marker CA 125 in the diagnosis of ovarian carcinoma. Methods: This study is integrative review, in which bibliographical surveys and analyzes of about 15 articles and scientific journals found in the databases: MEDLINE, LILACS, SCIELO, BIREME and PubMed, from 2005 to 2021 were carried out. In this review were included studies that focused on addressing the types of tumor markers (evidencing CA 125 and MUC 16). Results: Ovarian malignant epithelial neoplasia is evident among the types of tumors with aggressive malignancy that affect the female reproductive tract, as it is a disease that is difficult to control. Thus, the survival of these patients is well below the others, early diagnosis is of utmost importance. The CA125 biomarker was considered to have a high level of sensitivity. Final considerations: The CA125 biomarker serum it is unable to confirm the diagnosis alone, as it changes with other benign diseases, but it is widely used in clinical practice to aid in the diagnosis of ovarian cancer.