Abstract
Objective: Review and provide a comprehensive approach to systemic lupus erythematosus during pregnancy and provide updated information so that better outcomes can be achieved in high-risk pregnancies, achieving a better maternal-fetal prognosis. Literature Review: Systemic Lupus Erythematosus (SLE) is the most common autoimmune disease in pregnancy. Its clinical features are quite variable and, as the signs and symptoms are often nonspecific, it can mimic other diseases and make diagnosis more difficult. It is a disease that can affect different organs to different degrees. As SLE during pregnancy increases maternal and fetal risks, it is important to request laboratory tests for better control of the pregnant woman. Pregnancy monitoring should be multidisciplinary and include regular clinical, laboratory and ultrasound evaluation. Before getting pregnant, ideally, the pregnancy should be planned. Final considerations: Lupus can harm pregnancy and the baby, as well as pregnancy can exacerbate lupus, therefore, it is recommended to pregnant women rigorous medical monitoring before and after conception and especially during pregnancy.