Abstract
Objective: To review the literature on the influence of irisin on memory in patients with Alzheimer's disease, through physical exercise. Literature Review: Resistance physical exercise promotes positive effects on cognitive function and general brain plasticity, and may inhibit or delay the onset of neurodegenerative diseases, such as Alzheimer's disease, through the release of myokines into the bloodstream through endocrine activity contraction of muscle fibers. Irisin is a myokine capable of protecting the hippocampus, a region of the brain centrally involved in learning and memory, by stimulating the expression of neurotrophic factors, such as brain-derived neurotrophic factor, which is involved in neuroplasticity, neurogenesis, neuronal survival, synaptogenesis and cognition. Final Considerations: There is strong evidence that irisin is able to protect the hippocampus and influence the evolution of neurodegenerative diseases. However, larger-scale studies are still needed to clarify the relationship of these factors in the pathophysiology of Alzheimer's disease and, subsequently, the possible therapeutic content.