Abstract
Objective: To describe the main indications, as well as the possible disadvantages of the prolonged use of Proton Pumb Inhibitors (PPIs), based on a review of the current scientific literature. Literature review: PPIs are drugs that blocks gastric secretion, with the aim of increasing the pH of the gastric juice, through the inhibition of the enzyme H+/K+-ATPase. Thus, PPIs are considered effective, as long as they are ingested correctly, in the treatment of gastrointestinal disorders, such as peptic ulcers. The prolonged inhibitors usage without medical reassessment contributes to the emergence of adverse effects, as well as increasing the risk of dependence, which can also lead to Zollinger-Ellison (ZES), also called Hypergastrinemia, in addition to pharmacokinetic interactions and polypharmacy. Final considerations: There is no doubt about the effectiveness of PPIs in the treatment and prevention of gastric disorders. However, its high prevalence of use reinforces the importance of proper management and medical reassessment, including deprescription when there is no indication for use, in order to reduce the occurrence of adverse effects related to the long-term use of this drug.