Keywords
Aging
Neurology
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Abstract
Objective: To analyze the characteristics of Parkinson's Disease (PD). Bibliographic review: PD is a progressive disorder in which dopamine-producing cells located in the substantia nigra of the brain degenerate. It affects more than 10 million people worldwide, and this number is expected to double by 2030, given the aging of the world's population. The disease is characterized by a core set of movement (motor) abnormalities such as slowness of movement, muscle stiffness, and tremors, as well as a range of non-motor features such as constipation, anxiety, and dementia. Final considerations: PD is the second most common neurodegenerative disease with motor and non-motor symptoms that compromise the patient's quality of life. Its diagnosis is clinical based on the bradykinesia triad or slowness of movement associated with resting tremor and/or rigidity. Pharmacological treatment is done through dopamine replacement, but it does not provide a cure or delay the progression of the disease, acting only on its symptoms, being based on Carbidopa/Levodopa drugs. In addition, strategies such as complementary medicine and stimulation of physical activity are widely used in association with pharmacological therapy.
References
ALBERTS JL e ROSENFELD AB. The Universal Prescription for Parkinson's Disease: Exercise. J Parkinsons Dis, 2020; 10(1): 21-27.
AASETH J, et al. Prevention of progression in Parkinson's disease. Biometals, 2018; 31(5): 737-747.
ASSOGNA F, et al. Drug Choices and Advancements for Managing Depression in Parkinson's Disease. Curr Neuropharmacol, 2020; 18(4): 277-287.
AQUINO YC, et al. Respiratory disorders of Parkinson's disease. J Neurophysiol, 2022; 127(1): 1-15.
BANG Y, et al. Recent advances in the pathology of prodromal non-motor symptoms olfactory deficit and depression in Parkinson's disease: clues to early diagnosis and effective treatment. Arch Pharm Res, 2021; 44(6): 588-604.
BIDESI NSR, et al. The role of neuroimaging in Parkinson's disease. J Neurochem, 2021; 159(4): 660-689.
BUHMANN C, et al. Management of Pain in Parkinson's Disease. J Parkins Dis, 2020; 10(1): 37-48.
CHESLOW L, et al. Emerging targets for the diagnosis of Parkinson's disease: examination of systemic biomarkers. Biomark Med, 2021; 15(8): 597-608.
CHURCH FC. Treatment Options for Motor and Non-Motor Symptoms of Parkinson's Disease. Biomolecules, 2021; 11(4): 612.
DAY JO e MULLIN S. The Genetics of Parkinson's Disease and Implications for Clinical Practice. Genes (Basel), 2021; 12(7): 1006.
DEUEL LM e SEEBERGER LC. Complementary Therapies in Parkinson Disease: a Review of Acupuncture, Tai Chi, Qi Gong, Yoga, and Cannabis. Neurotherapeutics, 2020; 17(4): 1434-1455.
DIRKX MF e BOLOGNA M. The pathophysiology of Parkinson's disease tremor. J Neurol Sci, 2022; 435: 120196.
HALLI-TIERNEY AD, et al. Parkinson Disease. Am Fam Physician, 2020; 102(11): 679-691.
ISAACSON SH. Early Recognition and Diagnosis of Parkinson Disease and Ongoing Assessments. J Clin Psychiatry, 2019; 81(1): MS18003BR1C.
LI T e LE W. Biomarkers for Parkinson's Disease: How Good Are They? Neurosci Bull, 2020; 36(2): 183-194.
MAROGIANNI C, et al. Neurodegeneration and Inflammation-An Interesting Interplay in Parkinson's Disease. Int J Mol Sci, 2020; 21(22): 8421.
MIRANDA BR, et al. Preventing Parkinson's Disease: An Environmental Agenda. J Parkinsons Dis, 2022; 12(1): 45-68.
NG JSC. Palliative care for Parkinson's disease. Ann Palliat Med, 2018; 7(3): 296-303.
NUNES SFL, et al. Parkinson's disease in primary health care and nursing care: a scoping review. Rev Esc Enferm USP, 2022; 56: e20210367.
RADHAKRISHNAN DM e GOYAL V. Parkinson's disease: A review. Neurol India, 2018; 66(Supplement): 26-35.
SCHOOTEMEIJER S, et al. Current Perspectives on Aerobic Exercise in People with Parkinson's Disease. Neurotherapeutics, 2020; 17(4): 1418-1433.
SIMON DK, et al. Parkinson Disease Epidemiology, Pathology, Genetics, and Pathophysiology. Clin Geriatr Med, 2020; 36(1): 1-12.
TOLOSA E, et al. Challenges in the diagnosis of Parkinson's disease. Lancet Neurol, 2021; 20(5): 385-397.
TUETH LE e DUNCAN RP. Musculoskeletal pain in Parkinson's disease: a narrative review. Neurodegener Dis Manag, 2021; 11(5): 373-385.
WALLER S, et al. The initial diagnosis and management of Parkinson's disease. Aust J Gen Pract, 2021; 50(11): 793-800.
WEINTRAUB D, et al. The neuropsychiatry of Parkinson's disease: advances and challenges. Lancet Neurol, 2022; 21(1): 89-102.
ZHAO Y, et al. Acupuncture for Parkinson's Disease: Efficacy Evaluation and Mechanisms in the Dopaminergic Neural Circuit. Neural Plast, 2021; 2021: 9926445.