Abstract
Objective: To encourage the scientific community to carry out more specific and concrete studies aimed at associating periodontal disease with the onset of Alzheimer's disease. Bibliographic review: Among the various causes of Alzheimer's disease, this study stands out the possible relationship with periodontitis. Firstly, the bacteria causing periodontal disease carries a systemic inflammatory response exacerbated by the individual's defense cells, therefore, this inflammatory condition facilitates the development of Alzheimer's in susceptible people and amplifies the deleterious effects of people with dementia. Furthermore, the access of bacteria to the cerebral cortex through the trigeminal nerve and the consequent release of pro-inflammatory cytokines is a mechanism by which Periodontitis can be related to Alzheimer's disease. Further, the early treatment of periodontal disease can prevent the development of Alzheimer's disease. Final consideration: Thus, this review shows that Alzheimer's disease and Periodontitis can have a pathogenic relationship, however more studies need to be produced for this fact to be scientifically established.