Abstract
Objective: apresentate relative data for the two big pandemics that occurred on a period of 100 years of difference from each other: the Spanish Flu (1918–1920) and the SARS-CoV-2 (2019├), impactful for geopolitical, social and biologic aspects of humanity,in their respective times. Bibliographic review: the research has shown that these pandemics have similarities in some aspects, such as the rapid spread of the virus and high deaths; that SARS-CoV-2 have tested global health systems to the test, regardless the development of nations and motivating a race between laboratories, which provoke themselves to develop medicines and vaccines in the short term. Final considerations: from this study, it is understood that any pandemic has a gift of causing changes in people’s standard of living due to devastating effects; and the SARS-CoV-2, still expanding, is a challenge for the current scientific class, which seeks to discover, if not the cure, at least to control the disease.