Avanços no tratamento locorregional do câncer de próstata

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Matheus de Sousa Alves
Álvaro Moura e Silva
Gabriel Ribeiro Learth
Francisco Cairo Rios Santana
Thulio Mendes de Carvalho
Ícaro Emanoel de Sousa Borges
Victor Prudêncio Ibiapina de Morais
Vinicius Santana Vasconcelos
Igor da Rocha Martins Franklin
Francisco Danilo Fernandes do Nascimento

Resumo

Objetivo: Analisar as características do câncer de próstata e os avanços no diagnóstico e tratamento. Revisão bibliográfica: O câncer de próstata é o segundo tipo mais comum em homens, representando 29% dos diagnósticos de câncer masculino no Brasil. Localiza-se na glândula prostática, responsável pela produção do líquido seminal. Fatores de risco incluem idade avançada, histórico familiar e mutações nos genes BRCA1 e BRCA2. O diagnóstico é realizado por exame de toque retal, dosagem de PSA e escore de Gleason, que avalia a agressividade tumoral. No tratamento, destacam-se a radioterapia de intensidade modulada (IMRT), com maior precisão e menor toxicidade, e a radioterapia guiada por imagem, que aumenta a eficácia terapêutica. Além disso, a cirurgia robótica na prostatectomia radical oferece menor morbidade e melhor recuperação funcional. Considerações finais: O câncer de próstata apresenta alta incidência e impacto significativo na saúde masculina. Os avanços diagnósticos e terapêuticos, como a radioterapia hipofracionada e as técnicas cirúrgicas minimamente invasivas, têm contribuído para melhores desfechos clínicos, o que destaca a importância de uma abordagem personalizada e multidisciplinar para garantir qualidade de vida aos pacientes.

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Como Citar
AlvesM. de S., Silva Álvaro M. e, LearthG. R., SantanaF. C. R., CarvalhoT. M. de, Borges Ícaro E. de S., MoraisV. P. I. de, VasconcelosV. S., FranklinI. da R. M., & NascimentoF. D. F. do. (2025). Avanços no tratamento locorregional do câncer de próstata. Revista Eletrônica Acervo Científico, 25, e19766. https://doi.org/10.25248/reac.e19766.2025
Seção
Artigos

Referências

1. ACHARD V e ZILLI T. Prostate cancer intensity-modulated radiotherapy and long-term genitourinary toxicity: an evolving therapeutic landscape. Prostate Cancer and Prostatic Diseases, 2023; 26(1): 1-2.

2. BAUMAN G, et al. Intensity-modulated radiotherapy in the treatment of prostate cancer. Clinical Oncology, 2012; 24(7): 461-473.

3. BORGES-OSÓRIO MR e ROBINSON WM. Genética humana. 3rd ed. Porto Alegre: Artmed, 2013; 425.

4. BRASIL. Ministério da Saúde. Instituto Nacional de Câncer. Estadiamento. Rio de Janeiro: INCA, 2022.
Disponível em: https ://www.gov.br/inca/pt-br/assuntos/cancer/como-surge-o-cancer/estadiamento. Ace ssado em 10 de setembro de 2023.

5. BRASIL. Ministério da Saúde. Saúde do Homem. INCA - Instituto Nacional de Câncer. 2020. Disponível em: https ://www.inca.gov.br/campanhas/cancer-de-prostata/2020/saude-dohomem. Acessado em: 22 de novembro de 2023.

6. BRAVO BS, et al. Câncer de próstata: revisão de literatura / Prostate cancer: literature review. Brazilian Journal of Health Review, 2022; 5(1): 567-577.

7. CAO L, et al. Robot-assisted and laparoscopic vs open radical prostatectomy in clinically localized prostate cancer: perioperative, functional, and oncological outcomes: a systematic review and meta-analysis. Medicine (Baltimore), 2019; 98(22): 15770.

8. CARVALHO LM. Metástase óssea no câncer de próstata; 53 f. Trabalho de Conclusão de Curso (Graduação em Medicina) - Faculdade de Medicina; Universidade Federal Fluminense; Rio de Janeiro, 2022.

9. CHANG JY. Intensity-modulated radiotherapy, not 3-dimensional conformal, is the preferred technique for treating locally advanced lung cancer. Seminars in Radiation Oncology, 2015; 25(2): 110-116.

10. FICARRA V, et al. Systematic review and meta-analysis of studies reporting potency rates after robot-assisted radical prostatectomy. European Urology, 2012; 62(3): 418-430.

11. GAO L, et al. Autophagy and tumour radiotherapy. Advances in Experimental Medicine and Biology, 2020; 1207: 375-387.

12. HATANO K, et al. Current status of intensity-modulated radiation therapy for prostate cancer: history, clinical results and future directions. International Journal of Urology, 2019; 26(8): 775-784.

13. HUMMEL S, et al. Intensity-modulated radiotherapy for the treatment of prostate cancer: a systematic review and economic evaluation. Health Technology Assessment, 2010; 14(47): 1-108.

14. KING MT, et al. Low dose rate brachytherapy for primary treatment of localized prostate cancer: a systemic review and executive summary of an evidence-based consensus statement. Brachytherapy, 2021; 20(6): 1114-1129.

15. LANTZ A, et al. Functional and oncological outcomes after open versus robot-assisted laparoscopic radical prostatectomy for localised prostate cancer: 8-year follow-up. European Urology, 2021; 80(5): 650-660.

16. LAVERY HJ, et al. The advanced learning curve in robotic prostatectomy: a multi-institutional survey. Journal of Robotic Surgery, 2009; 3(3): 165.

17. LEE WR, et al. Randomized phase III noninferiority study comparing two radiotherapy fractionation schedules in patients with low-risk prostate cancer. Journal of Clinical Oncology, 2016; 34(20): 2325-2332.

18. MCCLELLAND S, et al. Is moderate hypofractionation accepted as a new standard of care in North America for prostate cancer patients treated with external beam radiotherapy? Survey of genitourinary expert radiation oncologists. International Brazilian Journal of Urology, 2019; 45(2): 273-287.

19. MCCORMICK BZ, et al. Contemporary outcomes following robotic prostatectomy for locally advanced and metastatic prostate cancer. Translational Andrology and Urology, 2021; 10(5).

20. MCLAUGHLIN PW e NARAYANA V. Progress in low dose rate brachytherapy for prostate cancer. Seminars in Radiation Oncology, 2020; 30(1): 39-48.

21. PICARDI C, et al. Hypofractionated radiotherapy for prostate cancer in the postoperative setting: what is the evidence so far? Cancer Treatment Reviews, 2018; 62: 91-96.

22. PODDER TK, et al. Advances in radiotherapy for prostate cancer treatment. Advances in Experimental Medicine and Biology, 2018; 1096: 31-47.

23. RABOY A, et al. Early experience with extraperitoneal endoscopic radical retropubic prostatectomy. Surgical Endoscopy, 1998; 12(10): 1264-1267.

24. RAJWA P, et al. Prostate cancer risk, screening and management in patients with germline BRCA1/2 mutations. Nature Reviews Urology, 2023; 20(4): 205-216.

25. SEKHOACHA M, et al. Prostate cancer review: genetics, diagnosis, treatment options, and alternative approaches. Molecules, 2022; 27(17): 5730.

26. SHEETS NC, et al. Intensity-modulated radiation therapy, proton therapy, or conformal radiation therapy and morbidity and disease control in localized prostate cancer. JAMA, 2012; 307(15): 1611-1620.

27. SIVKOV AV, et al. Brachytherapy for prostate cancer and immune response. Experimental and Clinical Urology, 2022; 15(3): 36-43.

28. SLEVIN F, et al. A comparison of outcomes for patients with intermediate and high-risk prostate cancer treated with low dose rate and high dose rate brachytherapy in combination with external beam radiotherapy. Clinical and Translational Radiation Oncology, 2020; 20: 1-8.

29. WANG G, et al. Genetics and biology of prostate cancer. Genes & Development, 2018; 32(17-18): 1105-1140.

30. YU T, et al. The effectiveness of intensity modulated radiation therapy versus three-dimensional radiation therapy in prostate cancer: a meta-analysis of the literature. PLoS ONE, 2016; 11(5): 154499.