The relationship between the consumption of ultra-processed food during pregnancy and the baby's neurological development

Main Article Content

Maria Eduarda Veloso
Beatriz Schneider Moresco
Caroline Taís Boiani dos Santos
Eduarda Ribas Nascimento
Henrique Steffens de Abreu
Luis Pedro Possapp Beis
Maria Eduarda Sponchiado Azevedo
Rafaela Turcato Strapazon
Suzana Karen Vilaça Alvim
Gabriel Cabeda Spalding Alves

Abstract

Objective: Analyze the influence of maternal nutrition during pregnancy on fetal neurological development, with an emphasis on the impact of consuming ultra-processed foods (UPFs). Literature review: A balanced diet, composed of essential macronutrients and micronutrients, is fundamental for the formation of the fetal nervous system, preventing cognitive deficits and metabolic diseases in adulthood. Pregnant women with inadequate diets, whether due to malnutrition or excessive calorie intake, may cause adverse consequences for the baby, such as low birth weight, neurological impairment, and an increased risk of chronic diseases. Excessive consumption of UPFs during pregnancy is associated with fetal neurodevelopmental issues, affecting brain structure and cognitive function. Excessive fats, sugars, and sodium can induce neuroinflammation, oxidative stress, and hormonal dysregulation, increasing susceptibility to disorders such as ADHD and autism. On the other hand, diets rich in proteins, iron, folate, and vitamin D promote proper brain development. Final considerations: Maternal nutrition plays a decisive role in fetal neurodevelopment, making nutritional guidance during pregnancy essential to minimize risks and promote the child's neurological health throughout life.

Article Details

How to Cite
VelosoM. E., MorescoB. S., dos SantosC. T. B., NascimentoE. R., de AbreuH. S., BeisL. P. P., AzevedoM. E. S., StrapazonR. T., AlvimS. K. V., & AlvesG. C. S. (2025). The relationship between the consumption of ultra-processed food during pregnancy and the baby’s neurological development. Revista Eletrônica Acervo Científico, 25, e20103. https://doi.org/10.25248/reac.e20103.2025
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Artigos

References

1. BANERJEE RR. Piecing together the puzzle of pancreatic islet adaptation in pregnancy: Pregnancy and pancreatic islets. Annals of the New York Academy of Sciences, 2018; 1411: 120-139.

2. BERGER PK, et al. Association of prenatal sugar consumption with newborn brain tissue organization. Nutrients, 2021; 13(7): 2435.

3. BOEUF P, et al. Plasmodium falciparum malaria elicits inflammatory responses that dysregulate placental amino acid transport. PLoS Pathogens, 2013; 9(2): 1003153.

4. CERNIGLIARO F, et al. Prenatal Nutritional Factors and Neurodevelopmental Disorders: A Narrative Review. Life (Basel), 2024; 14: 1084.

5. CORTÉS-ALBORNOZ MC, et al. Maternal Nutrition and Neurodevelopment: A Scoping Review. Nutrients, 2021; 13: 3530.

6. CUEVAS-SIERRA A, et al. Gut Microbiota differences according to ultra-processed food consumption in a Spanish population. Nutrients, 2021; 13: 2710.

7. DE OLIVEIRA PG, et al. Impacts of consumption of ultra-processed foods on the maternal-child health: A systematic review. Frontiers in nutrition, 2022; 9: 821657.

8. EDLOW AG. Maternal obesity and neurodevelopmental and psychiatric disorders in offspring. Prenatal Diagnosis, 2016; 37(1): 95–110.

9. FRERICHS NM, et al. Microbiome and its impact on fetal and neonatal brain development: current opinion in pediatrics. Current Opinion in Clinical Nutrition and Metabolic Care, 2024; 27: 297-303.

10. GAD EL-HAK HN, et al. Assessment of changes in the liver of pregnant female rats and their fetuses following monosodium glutamate administration. Environmental Science and Pollution Research International, 2021; 28(32): 44432–44441.

11. IONESCU MI, et al. Nurturing development: how a mother’s nutrition shapes offspring’s brain through the gut. Nutritional Neuroscience, 2025; 28: 50-72.

12. LIN L, et al. Nitrate contamination in drinking water and adverse reproductive and birth outcomes: a systematic review and meta-analysis. Scientific Reports, 2023; 13(1).

13. LINDSAY KL, et al. The Interplay Between Nutrition and Stress in Pregnancy: Implications for Fetal Programming of Brain Development. Biological Psychiatry, 2019; 85: 135-149.

14. MCCOLL ER, et al. Impact of inflammation and infection on the expression of amino acid transporters in the placenta: A minireview. Drug Metabolism and Disposition: The Biological Fate of Chemicals, 2022; 50(9): 1251–1258.

15. MITCHELL AJ, et al. The influence of maternal metabolic state and nutrition on offspring neurobehavioral development: A focus on preclinical models. Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, 2022; 7: 450-460.

16. MORALES-SUAREZ-VARELA M e ROCHA-VELASCO OA. Impact of ultra-processed food consumption during pregnancy on maternal and child health outcomes: A comprehensive narrative review of the past five years. Clinical nutrition ESPEN,2025; 65: 288–304.

17. NAAZ A e MUNESHWAR KN. How maternal nutritional and mental health affects child health during pregnancy: A narrative review. Cureus, 2023.

18. PAULA WO, et al. Maternal consumption of ultra-processed foods-rich diet and perinatal outcomes: A systematic review and meta-analysis. Nutrients, 2022; 14: 3242.

19. PUIG-VALLVERDÚ J, et al. The association between maternal ultra-processed food consumption during pregnancy and child neuropsychological development: A population-based birth cohort study. Clinical nutrition (Edinburgh, Scotland), 2022; 41(10): 2275–2283.

20. SHOOK LL, et al. Fetal brain and placental programming in maternal obesity: A review of human and animal model studies. Prenatal Diagnosis, 2020; 40: 1126-1137.

21. SZLAPINSKI SK e HILL DJ. Metabolic adaptations to pregnancy in healthy and gestational diabetic pregnancies: The pancreas-placenta axis. Current Vascular Pharmacology, 2021; 19: 141-153.

22. TALEBI S, et al. The association between ultra-processed food and common pregnancy adverse outcomes: a dose-response systematic review and meta-analysis. BMC Pregnancy and Childbirth, 2024; 24: 369.

23. URBONAITE G, et al. The impact of maternal high-fat diet on offspring neurodevelopment. Frontiers in Neuroscience, 2022; 16.

24. VIRDI S e JADAVJI NM. The impact of maternal folates on brain development and function after birth. Metabolites, 2022; 12(9): 876.

25. WECKMAN AM, et al. The impact of infection in pregnancy on placental vascular development and adverse birth outcomes. Frontiers in Microbiology, 2019; 10.

26. WHELAN K, et al. Ultra-processed foods and food additives in gut health and disease. Nature Reviews Gastroenterology & Hepatology, 2024; 21: 406-427.

27. ZHU Y, et al. Central obesity increases the risk of gestational diabetes partially through increasing insulin resistance: Central obesity and gestational diabetes. Obesity (Silver Spring, Md.), 2019; 27: 152-160.

28. ZUPO R, et al. Processed foods and diet quality in pregnancy may affect child neurodevelopment disorders: a narrative review. Nutritional Neuroscience, 2023; 27(4): 361–381.