Importance of using probiotics in modulating the intestinal microbiota for cognitive improvement in patients with Alzheimer's

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Kalidja da Conceição Rebouças de Souza Guedes
Tiago Bezerra de Sá de Sousa Nogueira
Raquel Bezerra de Sá de Sousa Nogueira

Abstract

Objective: To evaluate the effects of probiotics on microbiota modulation in patients with Alzheimer's disease. Methods: An integrative review was conducted based on the question “What are the benefits of probiotics on microbiota modulation in patients with AD?”. The research included full articles published between 2015 and 2025, in Portuguese and English, in the BVS, EMBASE, CAPES and PubMed databases. Ten studies were categorized by year, title, journal and database for detailed analysis. Results: Ten articles were obtained, of which 60% were published in A1 journals, 100% were published in English, and 30% included randomized clinical trials. In addition, 100% of the studies addressed the benefits of probiotics in cognitive domains. Modulation of the intestinal microbiota by probiotics demonstrated a positive impact on cognition. These results reinforce the gut-brain axis theory, where changes in the microbiota influence cognitive function. In addition, probiotics may help control inflammation and maintain neurochemical balance, essential processes in the context of AD. Final considerations: Probiotic supplementation shows promise in modulating the microbiota of patients with AD, with beneficial effects on cognition and quality of life.

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How to Cite
GuedesK. da C. R. de S., NogueiraT. B. de S. de S., & NogueiraR. B. de S. de S. (2025). Importance of using probiotics in modulating the intestinal microbiota for cognitive improvement in patients with Alzheimer’s. Revista Eletrônica Acervo Científico, 25, e20565. https://doi.org/10.25248/reac.e20565.2025
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Artigos

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