Pathophysiology and treatment of rheumatoid arthritis: a narrative review

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Published May 25, 2022
DOI https://doi.org/10.25248/reamed.e10106.2022

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Mateus Facklam Augusto
Universidade de Vassouras
Rhuan Victor Moreira da Silva
University of Vassouras
Juliana Teixeira Miquelito
University of Vassouras
Karine Grillo de Freitas
University of Vassouras
Victor Lucas Ferreira
University of Vassouras
Felipe Gomes Almeida Viana
University of Vassouras
Déborah Batista de Carvalho
University of Vassouras
Anderson Medeiros Filho
University of Vassouras
Emílio Conceição de Siqueira
University of Vassouras

Abstract

Objective: To review in a didactic way the pathophysiology and treatment of Rheumatoid Arthritis (RA). Bibliographic review: RA is a chronic inflammatory autoimmune disease that presents as a symmetrical polyarthritis. They have a worldwide and Brazilian prevalence of approximately 1%. The pathophysiology of RA is linked to the presence of a specific arthritogenic antigen that activates T lymphocytes, which together with the inflammatory cytokines released, cause the disease. The diagnosis of RA is made through the clinic with the help of criteria created by the American College of Rheumatology. Rheumatoid Factor (RF) and Anti-citrullinated Peptide Antibody (anti-CCP) are of great importance in the diagnosis of RA. The first line of treatment for RA is Disease-modifying Antirheumatic Drugs (DMARDs) alone or together with Non-steroidal Anti-inflammatory Drugs (NSAIDs), analgesics and/or glucocorticoids. Final considerations: RA is a pathology with a complex pathophysiology. Its rapid diagnosis is necessary for the best treatment for the patient.

Article Details

How to Cite
AugustoM. F., SilvaR. V. M. da, MiquelitoJ. T., FreitasK. G. de, FerreiraV. L., VianaF. G. A., CarvalhoD. B. de, Medeiros FilhoA., & SiqueiraE. C. de. (2022). Pathophysiology and treatment of rheumatoid arthritis: a narrative review. Revista Eletrônica Acervo Médico, 9, e10106. https://doi.org/10.25248/reamed.e10106.2022
Issue
Vol 9 (2022): Revista Eletrônica Acervo Médico (ISSN 2764-0485) | Volume 9 | 2022
Section
Revisão Bibliográfica

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References

1. ATZENI F, et al. Biomarkers in Rheumatoid Arthritis. The Israel Medical Association journal, 2017; 19(8): 512-516.

2. BULLOCK J, et al. Rheumatoid Arthritis: A Brief Overview of the Treatment. Medical principles and practice: international journal of the Kuwait University, 2018; 27(6): 501-507.

3. DELFT MAM, HUIZING TWJ. An overview of autoantibodies in rheumatoid arthritis. Journal of autoimmunity, 2020; 110: 102392

4. DERKSEN VFAM, et al. The role of autoantibodies in the pathophysiology of rheumatoid arthritis. Seminars in immunopathology, 2017; 39(4): 437-446.

5. FERRO F, et al. One year in review 2017: novelties in the treatment of rheumatoid arthritis. Clinical and experimental rheumatology, 2017; 35(5): 721-734.

6. GIOIA C, et al. Dietary Habits and Nutrition in Rheumatoid Arthritis: Can Diet Influence Disease Development and Clinical Manifestations?. Nutrients, 2020; 12(5): 1456.

7. HERNÁNDEZ-HERNÁNDEZ MV, DÍAZ-GONZÁLEZ F. Role of physical activity in the management and assessment of rheumatoid arthritis patients. Reumatologia clinica, 2017; 13(4): 214-220.

8. LIN YJ, et al. Update on the Pathomechanism, Diagnosis, and Treatment Options for Rheumatoid Arthritis. Cells, 2020; 9(4): 880.

9. LOPES ABLG. Imunoterapia e artrite reumatoide. Monografia (Mestrado Integrado em Ciências Farmacêuticas) - Universidade de Lisboa, Lisboa, 2019; 43 p.

10. LORA V, et al. Skin manifestations of rheumatoid arthritis. Giornale italiano di dermatologia e venereologia, 2018; 153(2): 243-255.

11. MCINNES IB, SCHETT G. Pathogenetic insights from the treatment of rheumatoid arthritis. Lancet, 2017; 389(10086): 2328-2337.

12. MEYER PWA, et al. Rheumatoid arthritis and risk of cardiovascular disease. Cardiovascular journal of Africa, 2018; 29(5): 317-321.

13. OLIVEIRA ALAV. Fisiopatologia da Artrite Reumatoide e seu impacto funcional comodoença crônica incapacitante. SEMPESq-Semana de Pesquisa da Unit-Alagoas, 2020; 8.

14. RADU AF, BUNGAU SG. Management of Rheumatoid Arthritis: An Overview. Cells, 2021; 10.

15. RODRIGUES, WF et al. Artrite reumatoide: fisiopatologia, diagnóstico e tratamento. Revista Saúde Multidisciplinar, 2017; 4: 37-57.

16. SANTOS JBR. Uso dos medicamentos biológicos para o tratamento da artrite reumatoide no sistema único de saúde: uma análise epidemiológica e econômica. Tese (Doutorado em Medicamentos e Assistência Farmacêutica) - Universidade Federal de Minas Gerais, Belo Horizonte, 2019, 147p.

17. SCHERER HU, et al. The etiology of rheumatoid arthritis. Journal of autoimmunity, 2020; 110: 102400.

18. VIÑOLAS LDV. Artrite Reumatoide – Abordagens Terapêuticas. Relatório de Estágio e Monografia (Mestrado Integrado em Ciências Farmacêuticas). Universidade de Coimbra, Coimbra, 2018, 48 p.

19. VOLKOV M, et al. Autoantibodies and B Cells: The ABC of rheumatoid arthritis pathophysiology. Immunological reviews, 2020; 294(1): 148-163.