Os efeitos da terapia de reposição hormonal em mulheres na menopausa
##plugins.themes.bootstrap3.article.sidebar##
##plugins.themes.bootstrap3.article.main##
Resumo
Objetivo: Expor os principais efeitos da terapia de reposição hormonal em diferentes sistemas do organismo feminino pós menopausa. Métodos: Revisão integrativa da literatura por meio de pesquisa bibliografica de abordagem qualitativa e caráter descritivo utilizando as bases de dados National Library of Medicine (PubMed)e Bivlioteca Virtual em Saúde (BVS). “Hormone Replacement Therapy” e “Menopause” foram os descritores utilizados, na lingua inglesa, que estão nos Descritores de Ciências da Saúde. Resultados: Todos os artigos revisados avaliaram benefícios e malefícios da prescrição de terapia de reposição hormonal em mulheres na pós-menopausa, produzindo um estudo de possíveis melhoras ou resultados negativos da medicação em vários cenários clínicos. Considerações finais: O estudo proposto considerou que a terapia de reposição hormonal apresenta riscos e benefícios que devem ser avaliados anteriormente a prescrição de qualquer tipo de hormônio. Mulheres que já apresentam sintomas graves e moderados principalmente de xerostomia, sintomas vulvovaginais e vasomotores, pode-se fazer necessário a utilização da terapia para melhora da qualidade de vida, devido à comprovação de sua eficácia. Para isso deve-se individualizar e realizar consultas periódicas para avaliação da melhora das queixas e nova conduta, caso seja possível a suspensão do medicamento.
##plugins.themes.bootstrap3.article.details##
Copyright © | Todos os direitos reservados.
A revista detém os direitos autorais exclusivos de publicação deste artigo nos termos da lei 9610/98.
Reprodução parcial
É livre o uso de partes do texto, figuras e questionário do artigo, sendo obrigatória a citação dos autores e revista.
Reprodução total
É expressamente proibida, devendo ser autorizada pela revista.
Referências
2. ZHANG L, et al. Menopausal Symptoms and Associated Social and Environmental Factors in Midlife Chinese Women. Clinical Interventions in Aging, 2020; (15): 2195-2208.
3. VELENTZIS LS, et al. Menopausal hormone therapy: Characterising users in an Australian national cross-sectional study. PLoS One, 2021; 16(8): e0253725.
4. SIMON JA, et al. Oral 17β-estradiol/progesterone (TX-001HR) and quality of life in postmenopausal women with vasomotor symptoms. Menopause, 2019; 26(5): 506–512.
5. CHLEBOWSKI RT, et al. Association of Menopausal Hormone Therapy With Breast Cancer Incidence and Mortality During Long-term Follow-up of the Women‘s Health Initiative Randomized Clinical Trials. JAMA, 2020; 324(4): 369-380.
6. MIRKIN S, et al. Relationship vasomotor symptom improvements and quality of life and sleep outcomes in menopausal women treated with oral, combined 17β-estradiol/progesterone. Menopause, 2019; 26(6): 637–642.
7. DIEM SJ, et al. Effects of vaginal estradiol tablets and moisturizer on menopause-specific quality of life and mood in healthy postmenopausal women with vaginal symptoms: a randomized clinical trial. Menopause, 2018; 25(10): 1086–1093.
8. GORDON JL, et al. The Effect of Perimenopausal Transdermal Estradiol and Micronized Progesterone on Markers of Risk for Arterial Disease. The Journal of Clinical Endocrinology & Metabolis, 2020; 105(5): 2050–2060.
9. HERRERA AY, et al. Estradiol Therapy After Menopause Mitigates Effects of Stress on Cortisol and Working Memory. The Journal of Clinical Endocrinology & Metabolism, 2017; 102(12): 4457–4466.
10. El KHOUDARY SR, et al. Heart fat and carotid artery atherosclerosis progression in recently menopausal women: impact of menopausal hormone therapy: The KEEPS trial. Menopause, 2020; 27(3): 255–262.
11. JAYACHANDRAN M, et al. Menopausal hormone therapy, blood thrombogenicity, and development of white matter hyperintensities in women of the Kronos Early Estrogen Prevention Study. Menopause, 2020; 27(3): 305–310.
12. Al-ROUSAN T, et al. Menopausal hormone therapy and the incidence of carpal tunnel syndrome in postmenopausal women: Findings from the Women's Health Initiative. PLoS One, 2018; 13(12): e0207509.
13. El KHOUDARY SR, et al. Effects of Hormone Therapy on Heart Fat and Coronary Artery Calcification Progression: Secondary Analysis From the KEEPS Trial. JAHA, 2019; 8(15): e012763
14. OBER BA, et al. Effects of Hormone Therapy on List and Story Recall in Post-Menopausal Women. Experimental Aging Research, 2019; 45(3): 199–222.
15. PRENTICE RL, et al. Randomized Trial Evaluation of the Benefits and Risks of Menopausal Hormone Therapy Among Women 50–59 Years of Age. American Journal of Epidemiology, 2021; 190(3): 365–375.
16. MANSON JE, et al. Menopausal Hormone Therapy and Long-term All-Cause and Cause-Specific Mortality: The Women’s Health Initiative Randomized Trials. JAMA, 2017; 318(10): 927.
17. SUH MJ, et al. Effects of endogenous and exogenous o estrogen exposure on hearing level in postmenopausal women: A cross‐sectional study. Clinical Otolaryngology, 2021; 46(3): 508–514.
18. JU R, et al. Sexual dysfunction in Chinese women at different reproductive stages and the positive effect of hormone replacement therapy in the early postmenopause. The European Journal of Contraception & Reproductive Health Care, 2021; 26(3): 246–54.
19. HANSEN ESH, et al. Hormone Replacement Therapy and Development of New Asthma. Chest, 2021; 160(1): 45–52.
20. KHIALANI D, et al. Venous thrombosis with oral postmenopausal hormone therapy: Roles of activated protein C resistance and tissue factor pathway inhibitor. J Thromb Haemost., 2021; 19(7): 1729–1737.
21. NWARU BI, et al. Hormone Replacement Therapy and Risk of Severe Asthma Exacerbation in Perimenopausal and Postmenopausal Women: 17-Year National Cohort Study. The Journal of Allergy and Clinical Immunology: In Practice, 2021; 9(7): 2751-2760.
22. PARK CW, et al. Fracture recurrence in hip fracture with menopausal hormone therapy versus risedronate: a clinical trial. Climacteric, 2021; 24(4): 408–414.
23. AHN SY, et al. The beneficial effects of menopausal hormone therapy on renal survival in postmenopausal Korean women from a nationwide health survey. Scientific Reports, 2021; 11(1):15418.
24. WANG L, et al. Role of hormone replacement therapy in relieving oral dryness symptoms in postmenopausal women: a case control study. BMC Oral Health, 2021; 615.