Dysbiosis and development of pre-eclampsia and eclampsia
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Abstract
Objective: Analyze the relationship between dysbiosis of the intestinal, vaginal and oral microbiomes with the development of preeclampsia and eclampsia. Methods: This integrative review involved searching studies in the National Library of Medicine, Latin America and the Caribbean Literature on Health and Cochrane Library databases, where fifteen articles on the topic were found, after selecting the inclusion and exclusion criteria. Results: All articles analyzed are of the clinical trial type. Among them, thirteen assess the intestinal microbiome, one assesses the vaginal microbiome and one simultaneously assesses the intestinal, vaginal and oral microbiomes. Final considerations: There are bacteria with protective action and others with deleterious action involved in the mechanism of pre-eclampsia pathophysiology. The intestinal barrier created by protective bacteria that produce short-chain fatty acids has anti-inflammatory and antioxidant effects that can prevent placental inflammation and consequently the development of PE, and it is through the investigation of the metabolites produced by these bacteria that it will be possible to focus targets for prevention and treatment of the disease.
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