A relação entre a microbiota intestinal e a função cognitiva

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Giovanna Marassi Florentino
Ramon Fraga de Souza Lima

Resumo

Objetivo: Identificar situações e patologias que atuam na interação da microbiota intestinal e na função cognitiva e com isso responder se há formas viáveis capazes de beneficiar essa relação, ou métodos de prevenção dos desfechos futuros de tais doenças. Métodos: Foi conduzida uma busca sistemática nas bases de dados Portal Regional da Biblioteca Virtual em Saúde (BVS) e a National Library of Medicine (PubMed), realizados entre os anos de 2019 a 2024, cujo os descritores foram “Cognitive Functions”; “microbiome intestinal”, utilizando o operador booleano “AND”. Resultados: A amostra final foi composta por 25 artigos, cuja maioria mostrou resultados positivos de alimentos utilizados com a finalidade de atuar no microbioma intestinal com desfecho aceitável na função cognitiva, além de mudanças no estilo de vida em pacientes com patologias que comprometem o sistema cognitivo, também foi possível evidenciar doenças que se desenvolviam com o declínio cognitivo e consequente prejuízo na composição da microbiota intestinal. Considerações finais: Nos estudos abordados, as patologias mostravam relação com alterações intestinais, seja na permeabilidade, seja na quantidade e espécies que compõe a microbiota e também foi possível determinar tipos de alimentos/probióticos, procedimentos e a pratica de atividade física como fatores viáveis à interação do eixo intestino-cérebro.

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Como Citar
FlorentinoG. M., & LimaR. F. de S. (2024). A relação entre a microbiota intestinal e a função cognitiva. Revista Eletrônica Acervo Médico, 24, e17095. https://doi.org/10.25248/reamed.e17095.2024
Seção
Revisão Bibliográfica

Referências

1. BAJAJ JS, et al. Microbial functional change is linked with clinical outcomes after capsular fecal transplant in cirrhosis. JCI insight, 2019; 4(24): 133410.

2. BELL L, et al. A randomized, placebo-controlled trial investigating the acute and chronic benefits of American Ginseng (Cereboost®) on mood and cognition in healthy young adults, including in vitro investigation of gut microbiota changes as a possible mechanism of action. European journal of nutrition, 2022; 61(1): 413-428.

3. DALILE B, et al. Colon-delivered short-chain fatty acids attenuate the cortisol response to psychosocial stress in healthy men: a randomized, placebo-controlled trial. Neuropsychopharmacology: official publication of the American College of Neuropsychopharmacology, 2020; 45(13): 2257-2266.

4. ENAUD R, et al. Gut Microbiota and Mycobiota Evolution Is Linked to Memory Improvement after Bariatric Surgery in Obese Patients: A Pilot Study. Nutrients, 2021; 13(11): 4061.

5. FEI Y, et al. Probiotic intervention benefits multiple neural behaviors in older adults with mild cognitive impairment. Geriatric nursing, 2023; 51: 167-175.

6. GAO W, et al. Gut microbiome and brain functional connectivity in infants-a preliminary study focusing on the amygdala. Psychopharmacology, 2019; 236(5): 1641–1651.

7. GHOSH TS et al. Mediterranean diet intervention alters the gut microbiome in older people reducing frailty and improving health status: the NU-AGE 1-year dietary intervention across five European countries. Gut, 2020; 69(7): 1218–1228.

8. GURIAN MBF, et al. Rastreamento da função cognitiva de idosos não-institucionalizados. Revista brasileira de geriatria e gerontologia, 2012; 15(2).

9. HASKELL-RAMSAY CF, et al. Mixed Tree Nuts, Cognition, and Gut Microbiota: A 4-Week, Placebo-Controlled, Randomized Crossover Trial in Healthy Nonelderly Adults. The Journal of nutrition, 2022; 152(12): 2778-2788.

10. HWANG YH, et al. Efficacy and Safety of Lactobacillus Plantarum C29-Fermented Soybean (DW2009) in Individuals with Mild Cognitive Impairment: A 12-Week, Multi-Center, Randomized, Double-Blind, Placebo-Controlled Clinical Trial. Nutrients, 2019; 11(2): 305.

11. KHINE WWT, et al. Mental awareness improved mild cognitive impairment and modulated gut microbiome. Aging, 2020; 12(23): 24371–24393.

12. KIM C-S, et al. Probiotic Supplementation Improves Cognitive Function and Mood with Changes in Gut Microbiota in Community-Dwelling Older Adults: A Randomized, Double-Blind, Placebo-Controlled, Multicenter Trial. The journals of gerontology. Series A, Biological sciences and medical sciences, 2021; 76(1): 32–40.

13. KONG XJ, et al. Probiotic and Oxytocin Combination Therapy in Patients with Autism Spectrum Disorder: A Randomized, Double-Blinded, Placebo-Controlled Pilot Trial. Nutrients, 2021; 13(5): 1552.

14. LEYROLLE Q, et al. Prebiotic effect on mood in obese patients is determined by the initial gut microbiota composition: A randomized, controlled trial. Brain, behavior, and immunity, 2021; 94: 289-298.

15. LI Y-M, et al. Correlations Between Gut Microbiota Changes and Cognitive Function in Patients with Post-Stroke Cognitive Impairment in the Early Stage. Sichuan Da Xue Xue Bao Yi Xue Ban, 2022; 53(5): 857-865.

16. LIANG X, et al. Gut microbiome, cognitive function and brain structure: a multi-omics integration analysis. Transl Neurodegener, 2022; 11: 49.

17. LIU P, et al. Altered microbiomes distinguish Alzheimer’s disease from amnestic mild cognitive impairment and health in a Chinese cohort. Brain, Behavior, and Immunity, 2019; 80: 633-643.

18. MEDAWAR E, et al. Prebiotic diet changes neural correlates of food decision-making in overweight adults: a randomised controlled within-subject cross-over trial. Gut, 2024; 73(2): 298-310.

19. MEYER K, et al. Association of the Gut Microbiota With Cognitive Function in Midlife. JAMA Netw Open, 2022; 5(2): 2143941.

20. PEREIRA AS et al. Metodologia da pesquisa científica. 2018.

21. REININGHAUS EZ, et al. PROVIT: Supplementary Probiotic Treatment and Vitamin B7 in Depression-A Randomized Controlled Trial. Nutrients, 2020; 12(11): 3422.

22. REITER A, et al. Interleukin-6 Gene Expression Changes after a 4-Week Intake of a Multispecies Probiotic in Major Depressive Disorder-Preliminary Results of the PROVIT Study. Nutrients, 2020; 12(9): 2575.

23. SOMETTI D, et al. Effects of the antibiotic rifaximin on cortical functional connectivity are mediated through insular cortex. Scientific reports, 2021; 11: 4479.

24. SOUZA SC. Revisão integrativa: o que é e como fazer. Einstein, 2010; 8(1): 102-6.

25. VAN SOEST APM, et al. Associations between Pro- and Anti-Inflammatory Gastro-Intestinal Microbiota, Diet, and Cognitive Functioning in Dutch Healthy Older Adults: The NU-AGE Study. Nutrients, 2020; 12(11): 3471.

26. WATTANATHOMN J, et al. A Randomized, Double-Blind, Placebo-Controlled Study of an Anthocyanin-Rich Functional Ingredient on Cognitive Function and Eye Dryness in Late Adulthood Volunteers: Roles of Epigenetic and Gut Microbiome Modulations. Nutrients 2023; 15(16): 3499.

27. YANG Y, et al. Altered fecal microbiota composition in individuals who abuse methamphetamine. Scientific reports, 2021; 11(1): 18178.

28. ZHU Y, et al. The impact of aerobic exercise training on cognitive function and gut microbiota in methamphetamine-dependent individuals in the community. Physiol Behav, 2023; 270: 114302.

29. ZORZO RA. Impacto do microbioma intestinal no Eixo Cérebro-Intestino. Jornal Internacional de Nutrologia, 2022; 10 (1): 298–305.