The Efficiency of New Technologies in Valve Calcification Therapeutics
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Abstract
Objective: To investigate how advances in the understanding of molecular mechanisms of valvular calcification can impact the development and efficacy of emerging therapies for the treatment of this condition, compared to traditional methods. Methods: An integrative literature review conducted in PubMed and the Virtual Health Library (VHL), focusing on articles published between 2019 and 2024. Relevant DeCS/MeSH descriptors such as calcification, RNA, valve calcification, and aortic valve calcification were used. Initially, 422 studies were identified and screened to include those addressing the molecular mechanisms of Aortic Valve Calcification (CAVD) and potential therapeutic interventions. Results: The analysis revealed significant advances with biomarkers such as cfDNA, IL-38, and microRNAs, as well as experimental therapies like vitamin K2, curcumin, and H₂S, which showed potential in inhibiting valvular calcification progression. Conclusions: New molecular therapies show promising results for treating valvular calcification. However, future studies should include larger and more diverse samples to validate their efficacy in different populations, thereby expanding the clinical applicability of these technologies.
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