Relação entre o desenvolvimento da resistência à insulina e a Síndrome do Ovário Policístico e seu manejo terapêutico

##plugins.themes.bootstrap3.article.main##

Maria Fernanda Ernesto Silva Quaresma
Cecília Américo de Almeida Martins
Ana Luísa Carvalho Ferreira
Clara Mendes David
Renata Aparecida Elias Dantas

Resumo

Objetivo: Analisar a relação da Síndrome do Ovário Policístico (SOP) com o desenvolvimento da resistência à insulina (RI), incluindo os tipos de tratamento envolvidos. Métodos: Consiste em uma revisão integrativa de literatura, realizada em setembro de 2024, nas bases de dados National Library of Medicine and National Institutes of Health (PubMed) e Biblioteca Virtual de Saúde (BVS). Os descritores utilizados, a partir dos Descritores em Ciências da Saúde (DeCS), foram “polycystic ovary syndrome” e “insulin resistance”, em conjunto com o operador booleano AND. Foram excluídas revisões sistemáticas, meta-análises e revisões de literatura e incluídos estudos de livre acesso, publicados entre 2019 e 2024. Resultados: Este artigo foi realizado a partir da análise de 15 estudos que abordam a relação da SOP com a resistência à insulina, contendo as intervenções necessárias para essas doenças. Os resultados encontrados foram apresentados nos Quadros 1 e 2, que incluem os autores e os principais achados. Considerações finais: Diante da análise do estudo, conclui-se que mulheres com SOP têm uma tendência maior a desenvolver RI e existem tratamentos que atenuam esses resultados.

##plugins.themes.bootstrap3.article.details##

Como Citar
QuaresmaM. F. E. S., MartinsC. A. de A., FerreiraA. L. C., DavidC. M., & DantasR. A. E. (2025). Relação entre o desenvolvimento da resistência à insulina e a Síndrome do Ovário Policístico e seu manejo terapêutico. Revista Eletrônica Acervo Médico, 25, e19187. https://doi.org/10.25248/reamed.e19187.2025
Seção
Revisão Bibliográfica

Referências

1. DIETZ DE LOOS A, et al. Metabolic health during a randomized controlled lifestyle intervention in women with PCOS. European Journal of Endocrinology, 2022; 186: 53-64.

2. FATIMA Q, et al. Evaluation of antioxidant defense markers in relation to hormonal and insulin parameters in women with polycystic ovary syndrome (PCOS): A case-control study. Diabetes & Metabolic Syndrome: Clinical Research & Reviews, 2019; 13: 1957-1961.

3. FREEMAN AM, et al. Insulin Resistance. Nih.gov, 2023.

4. HESHMATI J, et al. Effects of curcumin supplementation on blood glucose, insulin resistance and androgens in patients with polycystic ovary syndrome: A randomized double-blind placebo-controlled clinical trial. Phytomedicine, 2021; 80: 153395.

5. JABARPOUR M, et al. Astaxanthin supplementation impact on insulin resistance, lipid profile, blood pressure, and oxidative stress in polycystic ovary syndrome patients: A triple-blind randomized clinical trial. Phytotherapy research: PTR, 2024; 38: 321-330.

6. LEJMAN-LARYSZ K, et al. Influence of vitamin D on the incidence of metabolic syndrome and hormonal balance in patients with polycystic ovary syndrome. Nutrients, 2023; 15: 2952.

7. LI X, et al. The risk factors of gestational diabetes mellitus in patients with polycystic ovary syndrome. Medicine, 2021; 100: 26521.

8. LIVADAS S, et al. Insulin resistance, androgens, and lipids are gradually improved in an age-dependent manner in lean women with polycystic ovary syndrome: insights from a large Caucasian cohort. Hormones, 2020; 19: 531-539.

9. MA R, et al. Short-term combined treatment with exenatide and metformin for overweight/ obese women with polycystic ovary syndrome. Chinese Medical Journal, 2021; 134: 2882-2889.

10. MAFFAZIOLI GDN, et al. Prevalence of metabolic disturbances among women with polycystic ovary syndrome in different regions of Brazil. International Journal of Gynecology & Obstetrics, 2020; 151: 383-391.

11. MORGANTE G, et al. Metformin doses and body mass index: clinical outcomes in insulin resistant polycystic ovary syndrome women. European review for medical and pharmacological sciences, 2020; 24: 8136-8142.

12. RONDANELLI M, et al. Berberine phospholipid is an effective insulin sensitizer and improves metabolic and hormonal disorders in women with polycystic ovary syndrome: A one-group pretest-post-test explanatory study. Nutrients, 2021; 13: 3665.

13. RYU K, et al. Risk of type 2 diabetes is increased in nonobese women with polycystic ovary syndrome: the National Health Insurance Service-National Sample Cohort Study. Fertility and Sterility, 2021; 115: 1569-1575.

14. SHAHMORADI S, et al. The effect of magnesium supplementation on insulin resistance and metabolic profiles in women with polycystic ovary syndrome: a randomized clinical trial. Biological Trace Element Research, 2023; 202: 941-946.

15. WEN Q, et al. Effect of acupuncture and metformin on insulin sensitivity in women with polycystic ovary syndrome and insulin resistance: a three-armed randomized controlled trial. Human Reproduction, 2021; 37: 542-552.

16. WHO. WORLD HEALTH ORGANIZATION. 2023. In: Polycystic ovary syndrome. Disponível em: https ://www.who.int/news-room/fact-sheets/detail/polycystic-ovary-syndrome. Acesso em: 6 nov. 2024.