Influência da modulação da microbiota intestinal nos sintomas do Transtorno do Espectro Autista
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Publicado
Jul 23, 2025
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Resumo
Objetivo: Analisar a modulação da microbiota intestinal e seus impactos nos sintomas do Transtorno do Espectro Autista. Métodos: Trata-se de uma revisão integrativa realizada, no idioma português, nas bases de dados Pubmed, Scopus e BVS. Para inclusão dos artigos foram utilizados os seguintes critérios: artigos em língua inglesa e espanhola publicados entre os anos de 2020 a 2025, com abordagem da modulação da microbiota em pessoas com TEA. Já os critérios de exclusão foram revisões sistemáticas, metanálises, artigos de opinião, teses de doutorado e dissertações. Resultados: Dos estudos selecionados, a intervenção com prebióticos, probióticos, simbióticos e/ou transplante de microbiota fecal em pessoas com TEA resultaram na alteração da microbiota intestinal, no padrão comportamental e melhora nos sintomas gastrointestinais. Considerações finais: Pode se considerar que alterações na microbiota intestinal são frequentemente observadas em indivíduos com Transtorno do Espectro Autista e estão, muitas vezes, relacionadas a sintomas gastrointestinais e comportamentais. As intervenções com probióticos, prebióticos, simbióticos e transplante de microbiota fecal surgem como estratégias promissoras.
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Como Citar
SoaresA. B. F., FerreiraB. V. G., LoiolaG. R., RibeiroN. A. N. F., & BarbosaJ. P. de S. (2025). Influência da modulação da microbiota intestinal nos sintomas do Transtorno do Espectro Autista. Revista Eletrônica Acervo Médico, 25, e21098. https://doi.org/10.25248/reamed.e21098.2025
Seção
Revisão Bibliográfica
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Referências
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13. KONG XJ, et al. Probiotic and oxytocin combination therapy in patients with autism spectrum disorder: a randomized, double-blinded, placebo-controlled pilot trial. Nutrients, 2021; 13: 1-17.
14. LI H, et al. Alteration of the gut microbiota profile in children with autism spectrum disorder in China. Frontiers in Microbiology, 2024; 14: 1-12
15. LI N, et al. Fecal microbiota transplantation relieves gastrointestinal and autism symptoms by improving the gut microbiota in an open-label study. Frontiers Cellular Infection Microbiology, 2021; 11: 1-13.
16. LI Y, et al. Omic characterizing and targeting gut dysbiosis in children with autism spectrum disorder: symptom alleviation through combined probiotic and medium-carbohydrate diet intervention - a pilot study. Gut Microbes, 2024;16(1): 2434675.
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18. MARQUES SMS, et al. Métodos de pesquisa: revisão sistemática, revisão integrativa e pesquisa documental. Contribuciones a las ciencias sociales, 2025; 18(2): 1-15.
19. MITCHELL LK, et al. Gastrointestinal, Behaviour and Anxiety Outcomes in Autistic Children Following an Open Label, Randomised Pilot Study of Synbiotics vs Synbiotics and Gut-Directed Hypnotherapy. Journal of autism and developmental disorders, 2025; 55(1): 391.
20. MORENO X, et al. Relación de niveles de zinc y cobre con disbiosis intestinal en niños con trastorno autista. Archivos Venezolanos de puericultura y pediatria, 2021; 84: 4–10.
21. NAKAZAWA-MIKLASEVICA M, et al. Alterations of Gut Microbiota among Children with Autism Spectrum Disorder. Molecular Genetics Microbiology and Virology, 2021; 36(S1): S29-S36.
22. NOVAU-FERRÉ N, et al. Gut microbiome differences in children with attention deficit hyperactivity disorder and autism spectrum disorder and effects of probiotic supplementation: a randomized controlled trial. Research in developmental disabilities, 2025; 161: 1-12.
23. PALMER JK, et al. A double-blind randomised controlled trial of prebiotic supplementation in children with autism: effects on parental quality of life, child behaviour, gastrointestinal symptoms, and the microbiome. Journal of autism and developmental disorders, 2025; 55: 775-788.
24. PAN ZY, et al. Beneficial effects of repeated washed microbiota transplantation in children with autism. Front. Pediatr., 2022; 10: 928785.
25. PANDA, PK et al. Efficacy of oral folinic acid supplementation in children with autism spectrum disorder: a randomized double-blind, placebo-controlled trial.European journal of pediatrics, 2024; 183(11): 4827–4835.
26. RETUERTO M, et al. Analysis of gut bacterial and fungal microbiota in children with autism spectrum disorder and their non-autistic siblings. Nutrients, 2024; 16(17): 3004.
27. VASCONCELOS QDJS, et al. Effects of whey protein supplementation on gut microbiota of Wistar rats with valproic acid-induced autism symptoms. Future Microbiology, 2023; 19: 213-226.
28. VINDIGNI SM, SURAWICZ C. Fecal microbiota transplantation. Gastroenterology Clinics of North America, 2017; 46(1): 171-185.
29. WANG H, et al. Gut microbiota signature in children with autism spectrum disorder who suffered from chronic gastrointestinal symptoms. BMC Pediatrics, 2023; 23(1): 476.
30. WANG Q, et al. The microbiota–gut–brain axis and neurodevelopmental disorders. Protein & Cell, 2023; 14(10): 762-775.
31. WANG Y, et al. Probiotics and fructo-oligosaccharide intervention modulate the microbiota-gut brain axis to improve autism spectrum reducing also the hyper-serotonergic state and the dopamine metabolism disorder. Pharmacological Research, 2020; 157: 104784.
32. ZHANG L, et al. The role of probiotics in children with autism spectrum disorders: A study protocol for a randomised controlled trial. PloS One, 2022; 17(2): 0263109.
33. ZHAO Y, et al. Altered Gut Microbiota as Potential Biomarkers for Autism Spectrum Disorder in Early Childhood. Neuroscience, 2023; 523: 118–131.
2. ALLAN NP, et al. Ketogenic Diet Induced Shifts in the Gut Microbiome Associate with Changes to Inflammatory Cytokines and Brain-Related miRNAs in Children with Autism Spectrum Disorder. Nutrients, 2024; 16 (10): 1401.
3. BILLECI L, et al. A randomized controlled trial into the effects of probiotics on electroencephalography in preschoolers with autism. Autism, 2022; 27(1): 117-132.
4. CHEN Y, et al. Causal effects of gut microbiota on autism spectrum disorder: A two-sample mendelian randomization study. Medicine, 2024; 103(9): e37284.
5. DARWESH MAK, et al. Unraveling the relative abundance of psychobiotic bacteria in children with autism spectrum disorder. Nature Scientific Reports, 2024; 14(1): 1-12.
6. DUQUE ALRF et al. Effect of probiotic, prebiotic, and synbiotic on the gut microbiota of autistic children using an in vitro gut microbiome model. Food Research International, 2021; 149: 110657.
7. FLESCH AGT, et al. O uso terapêutico dos simbióticos. ABCD Arquivos Brasileiros de Cirurgia Digestiva, 2014; 27(3): 206-209.
8. FRANCA GM, et al. Efeito imunomodulador da microbiota intestinal, as consequências de seu desequilíbrio e a profilaxia probiótica. Revista Ibero-Americana de Humanidades, Ciências e Educação, 2021; 7(9): 151-175.
9. GUIDETTI C, et al. Randomized Double-Blind Crossover Study for Evaluating a Probiotic Mixture on Gastrointestinal and Behavioral Symptoms of Autistic Children. Journal of Clinical Medicine, 2022;. 11(18): 5263.
10. HEIJTZ RD, et al. Normal gut microbiota modulates brain development and behaviour. Proceedings of the National Academy of Sciences 2011; 108(7): 3047-3052.
11. HRNCIAROVA J, et al. Modulation of gut microbiome and autism symptoms of ASD children supplemented with biological response modifier: a randomized, double-blinded, placebo-controlled pilot study. Nutrients, 2024; 16: 1-14.
12. KANG DW, et al. Long-term benefit of Microbiota Transfer Therapy on autism symptoms and microbiota. Scientific Report, 2019; 9: 5821
13. KONG XJ, et al. Probiotic and oxytocin combination therapy in patients with autism spectrum disorder: a randomized, double-blinded, placebo-controlled pilot trial. Nutrients, 2021; 13: 1-17.
14. LI H, et al. Alteration of the gut microbiota profile in children with autism spectrum disorder in China. Frontiers in Microbiology, 2024; 14: 1-12
15. LI N, et al. Fecal microbiota transplantation relieves gastrointestinal and autism symptoms by improving the gut microbiota in an open-label study. Frontiers Cellular Infection Microbiology, 2021; 11: 1-13.
16. LI Y, et al. Omic characterizing and targeting gut dysbiosis in children with autism spectrum disorder: symptom alleviation through combined probiotic and medium-carbohydrate diet intervention - a pilot study. Gut Microbes, 2024;16(1): 2434675.
17. LORD C, et al. Autism Spectrum Disorder. The Lancet, 2018; 392: 508-520.
18. MARQUES SMS, et al. Métodos de pesquisa: revisão sistemática, revisão integrativa e pesquisa documental. Contribuciones a las ciencias sociales, 2025; 18(2): 1-15.
19. MITCHELL LK, et al. Gastrointestinal, Behaviour and Anxiety Outcomes in Autistic Children Following an Open Label, Randomised Pilot Study of Synbiotics vs Synbiotics and Gut-Directed Hypnotherapy. Journal of autism and developmental disorders, 2025; 55(1): 391.
20. MORENO X, et al. Relación de niveles de zinc y cobre con disbiosis intestinal en niños con trastorno autista. Archivos Venezolanos de puericultura y pediatria, 2021; 84: 4–10.
21. NAKAZAWA-MIKLASEVICA M, et al. Alterations of Gut Microbiota among Children with Autism Spectrum Disorder. Molecular Genetics Microbiology and Virology, 2021; 36(S1): S29-S36.
22. NOVAU-FERRÉ N, et al. Gut microbiome differences in children with attention deficit hyperactivity disorder and autism spectrum disorder and effects of probiotic supplementation: a randomized controlled trial. Research in developmental disabilities, 2025; 161: 1-12.
23. PALMER JK, et al. A double-blind randomised controlled trial of prebiotic supplementation in children with autism: effects on parental quality of life, child behaviour, gastrointestinal symptoms, and the microbiome. Journal of autism and developmental disorders, 2025; 55: 775-788.
24. PAN ZY, et al. Beneficial effects of repeated washed microbiota transplantation in children with autism. Front. Pediatr., 2022; 10: 928785.
25. PANDA, PK et al. Efficacy of oral folinic acid supplementation in children with autism spectrum disorder: a randomized double-blind, placebo-controlled trial.European journal of pediatrics, 2024; 183(11): 4827–4835.
26. RETUERTO M, et al. Analysis of gut bacterial and fungal microbiota in children with autism spectrum disorder and their non-autistic siblings. Nutrients, 2024; 16(17): 3004.
27. VASCONCELOS QDJS, et al. Effects of whey protein supplementation on gut microbiota of Wistar rats with valproic acid-induced autism symptoms. Future Microbiology, 2023; 19: 213-226.
28. VINDIGNI SM, SURAWICZ C. Fecal microbiota transplantation. Gastroenterology Clinics of North America, 2017; 46(1): 171-185.
29. WANG H, et al. Gut microbiota signature in children with autism spectrum disorder who suffered from chronic gastrointestinal symptoms. BMC Pediatrics, 2023; 23(1): 476.
30. WANG Q, et al. The microbiota–gut–brain axis and neurodevelopmental disorders. Protein & Cell, 2023; 14(10): 762-775.
31. WANG Y, et al. Probiotics and fructo-oligosaccharide intervention modulate the microbiota-gut brain axis to improve autism spectrum reducing also the hyper-serotonergic state and the dopamine metabolism disorder. Pharmacological Research, 2020; 157: 104784.
32. ZHANG L, et al. The role of probiotics in children with autism spectrum disorders: A study protocol for a randomised controlled trial. PloS One, 2022; 17(2): 0263109.
33. ZHAO Y, et al. Altered Gut Microbiota as Potential Biomarkers for Autism Spectrum Disorder in Early Childhood. Neuroscience, 2023; 523: 118–131.