Keywords
Wound healing
Therapeutics
Interleukins
How to Cite
Copyright © | All rights reserved.
The journal holds the exclusive copyright for the publication of this article under the terms of Brazilian law 9610/98.
Partial reproduction
The use of parts of the texts, figures and questionnaire of the article is free, being mandatory the citation of the authors and journal.
Total reproduction
It is expressly prohibited and must be authorized by the journal.
Abstract
Objective: To review the scientific literature on the mechanism of action and possible clinical applicability of Platelet Rich Fibrin (PRF) in the field of medicine. Bibliographic review: PRF is a platelet concentrate rich in growth factors, leukocytes and platelets. This product aims to promote tissue regeneration more efficiently and quickly. To obtain it, fresh blood is used and centrifuged, gathering the most active components of the sample. These components, added to neutrophils and platelets, promote tissue regeneration. Currently, PRF is experimental in medicine, although it is used for dental purposes, improving healing in surgical procedures. In the studies presented, the results have been positive regarding its use in skin continuity lesions and for aesthetic purposes. Final considerations: The analyzed studies showed that from its rich arsenal of growth factors, PRF has shown satisfactory results in the healing of several injuries and in the reduction of the patient's recovery time. Thus, PRF emerges as a new approach to tissue repair.
References
ANITUA E, et al. Autologus fibrin scaffolds: When platelet-and plasma derived biomolecules meet fibrin. Biomaterials, 2019; 192: 440-460.
BILGEN F, et al. Platelet-rich fibrin: na effective chronic wound healing accelerator. Journal of Tissue Viability, 2021; 30(4): 616-620.
CHOUKROUN J, et al. Platelet-rich fibrin (PRF): A second-generation platelet concentrate. Part IV: Clinical effects on tissue healing. Oral and Maxillofacial Surgery, 2006; 101 (3): e56-e60.
DEVEREAUX J, et al. Leucocyte-rich platelet-rich plasma enhances fibroblast and extracellular matrix activity: Implications in wound healing. International Journal of Molecular Sciences, 2020; 21 (18): 1-17.
DING Y, et al. Platelet-Rich Fibrin Accelerates Skin Wound Healing in Diabetic Mice. Annals of plastic surgery, 2017; 79 (3): e15-e19.
FAN Y, et al. Clinical Uses of Platelet-Rich Fibrin in Oral and Maxillofacial Surgery. Dent Clin N Am, 2020; 64(2): 291-303.
GRECU AF, et al. Platelet-Rich Fibrin and Its Emerging Therapeutic Benefits for Musculoskeletal Injury Treatment. Medicina, 2019; 55 (5): 1-12.
KARIMI K, ROCKWELL H. The Benefits of Platelet-Rich Fibrin. Facial Plast Surg Clin N Am, 2019; 27(3): 331-340.
MATRAS H. Effect of various fibrin preparations on reimplantations in the rat skin. Osterr Z Stomatol, 1970; 67: 338–59.
MIRON RJ, et al. Platelet-Rich Fibrin and Soft Tissue Wound Healing: A Systematic Review. Tissue Engineering - Part B: Reviews, 2017; 23 (1): 83-99.
NASIRZADE J, et al. Platelet-rich fibrin elicits an anti-inflammatory response in macrophages in vitro. Journal of periodontology, 2020; 91 (2): 244-252.
OZER K, COLAK O. Leucocyte- and platelet-rich fibrin as a rescue therapy for small-to-medium-sized complex wounds of the lower extremities. Burn Trauma, 2019; 7(1): 1–9.
PAVLOVIC V, et al. Platelet-rich fibrina: Basics of biological actions and protocol modifications. Open Medicine, 2021; 16: 446-454.
PINTO NR, et al. Leucocyte and platelet-rich (L-PRF) as a regenerative medicine strategy for the treatment of refractory leg ulcers: a prospective cohort study. Platelets, 2019; 29 (5): 468-475.
SARI H, et al. The effect of platelet-rich fibrina (PRF) on wound healing, adhesion, and hemostasis after endoscopic sinus surgery in patientswith nasal polyposis. Am J Otolaryngol – Head Neck Med Surg, 2021; 42 (5): 103010.
SCHULZ A, et al. Does platelet-rich fibrin enhance healing of burn wounds? Our first experiences and main pitfalls. Annals of Burns and Fire Disasters, 2021; 34 (1): 42-52.
TAKAMORI ER, et al. Fibrina rica em plaquetas: preparo, definição da qualidade, uso clínico. Vigilância Sanitária em Debate, 2018; 6(1): 118-124.
VAHEB M, et al. Evaluation of the Effect of Platelet-Rich Fibrin on Wound Healing at Split-Thickness Skin Graft Donor Sites: A Randomized, Placebo-Controlled, Triple-Blind Study. International Journal of Lower Extremity Wounds, 2021; 20 (1): 29–36.
ZHAO R, et al. Inflammation in chronic wounds. Int J Mol Sci. 2016; 17(12): 1–14.