Abstract
Objective: To analyze the characteristics of Atopic Dermatitis (AD). Bibliography review: AD is the most prevalent chronic inflammatory skin condition worldwide with a relapsing character that repeatedly goes through the following stages: exacerbation and improvement. A family history of atopic disease, including asthma and allergic rhinitis, predisposes to the development of AD. Its pathophysiology comprises skin barrier dysfunction and immune dysregulation. The main symptom of AD is pruritus, which is associated with mental suffering and the development of depression and anxiety. Final considerations: AD is a disease associated with genetic and environmental factors, mainly characterized by pruritus and eczema that causes a decrease in patients' quality of life. Its therapy includes, in addition to the prevention of environmental factors, skin hydration, the use of topical corticosteroids and systemic medications in more severe cases. In this sense, a correct diagnosis and multidisciplinary treatment of these patients is essential, aiming not only at disease control and infection prevention, but also at psychological care in order to avoid the development of depressive and anxiety disorders.
References
AHN K, et al. Recent advances in atopic dermatitis. Curr Opin Immunol, 2020; 66:14-21.
ABUABARA K, et al. The Long-Term Course of Atopic Dermatitis. Dermatol Clin, 2017; 35(3): 291- 297.
ALI F, et al. Counting the Burden: Atopic Dermatitis and Health-related Quality of Life. Acta Derm Venereol, 2020; 100(12):adv00161.
AVENA-WOODS C. Overview of atopic dermatitis. Am J Manag Care, 2017; 23(8): S115-S123.
BROWN SJ, et al. Genetics in Atopic Dermatitis: Historical Perspective and Future Prospects. Acta Derm Venereol, 2020; 100(12): adv00163.
BYLUND S, et al. Prevalence and Incidence of Atopic Dermatitis: A Systematic Review. Acta Derm Venereol, 2020; 100(12): adv00160.
BRUNNER PM, et al. Immunologic, microbial, and epithelial interactions in atopic dermatitis. Ann Allergy Asthma Immunol, 2018; 120(1): 34-41.
EDSLEV SM, et al. Skin Microbiome in Atopic Dermatitis. Acta Derm Venereol, 2020; 100(12): adv00164.
EZZEDINE K, et al. Impact of Atopic Dermatitis in Adolescents and their Parents: A French Study. Acta Derm Venereol, 2020; 100(17): adv00294.
FISHBEIN AB, et al. Update on Atopic Dermatitis: Diagnosis, Severity Assessment, and Treatment Selection. J Allergy Clin Immunol Pract, 2020; 8(1): 91-101.
FLEMING P, et al. Diagnosis and Management of Atopic Dermatitis for Primary Care Providers. J Am Board Fam Med, 2020; 33(4):626-635. .
FRAZIER W, BHARDWAJ N. Atopic Dermatitis: Diagnosis and Treatment. Am Fam Physician, 2020; 101(10): 590-598.
FUJI M. Current Understanding of Pathophysiological Mechanisms of Atopic Dermatitis: Interactions among Skin Barrier Dysfunction, Immune Abnormalities and Pruritus. Biol Pharm Bull, 2020; 43(1):12-19.
GERNER T, et al. Atopic dermatitis. Ugeskr Laeger, 2018; 180(4): V04170331.
JOHANSSON EK. Psychiatric conditions in children with atopic dermatitis. Br J Dermatol, 2021; 185(1):8-9.
KAUPPI S, et al. Adult Patients with Atopic Eczema have a High Burden of Psychiatric Disease: A Finnish Nationwide Registry Study. Acta Derm Venereol, 2019; 99(7): 647-651.
KIM J, et al. Pathophysiology of atopic dermatitis: Clinical implications. Allergy Asthma Proc, 2019; 40(2):84-92.
KULTHANAN K, et al. Clinical practice guidelines for the diagnosis and management of atopic dermatitis. Asian Pac J Allergy Immunol, 2021; 39(3):145-155.
LIN TK, et al. Association between Stress and the HPA Axis in the Atopic Dermatitis. Int J Mol Sci, 2017; 18(10): 2131.
NA CH, et al. A Therapeutic Renaissance - Emerging Treatments for Atopic Dermatitis. Acta Derm Venereol, 2020; 100(12):adv00165.
NARLA S, SILVERBERG JI. Dermatology for the internist: optimal diagnosis and management of atopic dermatitis. Ann Med, 2021; 53(1):2165-2177.
NAKATSUJI T, GALLO RL. The role of the skin microbiome in atopic dermatitis. Ann Allergy Asthma Immunol, 2019; 122(3):263-269.
ROBINSON RG, SINGH AM. Controversies in Allergy: Food Testing and Dietary Avoidance in Atopic Dermatitis. J Allergy Clin Immunol Pract, 2019; 7(1):35-39.
SOUTO EB, et al. Trends in Atopic Dermatitis-From Standard Pharmacotherapy to Novel Drug Delivery Systems. Int J Mol Sci, 2019; 20(22):5659.
TAMAGAWA-MINEKOA R, KATOH N. Atopic Dermatitis: Identification and Management of Complicating Factors. Int J Mol Sci, 2020; 21(8):2671.
TRAIDL S, WERFEL T. Allergen immuntherapie bei atopischer Dermatitis [Allergen immunotherapy for atopic dermatitis]. Hautarzt, 2021; 72(12):1103-1112.
YANG G, et al. Skin Barrier Abnormalities and Immune Dysfunction in Atopic Dermatitis. Int J Mol Sci, 2020; 21(8): 2867.
WANG V, et al. The infectious complications of atopic dermatitis. Ann Allergy Asthma Immunol, 2021; 126(1): 3-12.
