Keywords
Anti-bacterial agents
Drug resistance multiple bacteria
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Abstract
Objective: To investigate the efficacy of bacteriophages against ultra-resistant bacteria. Methods: The Scopus, U.S. National Library of Medicine National Institutes of Health (PubMed), and Latin American and Caribbean Health Sciences Literature (LILACS) databases were searched. Descriptors “bacterial infections OR bacteria Infections” AND “phage therapy OR phage therapy” AND “antibacterials OR antibacterial agents” AND “treatment result OR treatment result” NOT “review OR review”. Original articles published in Portuguese or English in the last 3 years were selected. A total of 1,072 articles were found, using the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) methodology. Results: Study of 17 articles on the effectiveness of bacteriophage therapy in antioxidant microorganisms. The following were highlighted: article code, author, year of publication, type of study, intervention, and main development. Categorization into groups: ineffectiveness of treatment, effectiveness with bacteriophages alone, and effectiveness with bacteriophages in synergy with antibiotics, indicating that the latter group is more effective than the other two. Final considerations: The use of phage therapy may be a promising alternative for bacterial infections, so there is a need for research to better understand the mechanisms of action of bacteriophages and improve their clinical use.
References
AJMAL H, et al. Biological and physical characterization of bacteriophage JHA against multidrug-resistant Acinetobacter baumannii. Pakistan journal of pharmaceutical sciences, 2022; 35(5): 1327-1331.
ALTAMIRANO FG, et al. Acinetobacter baumannii resistentes a bacteriófagos são ressensibilizados a antimicrobianos. Nature microbiology, 2021; 6(2): 157-161.
FANAEI V, et al. Isolamento e identificação de bacteriófagos específicos contra Staphylococcus aureus resistente à meticilina, Escherichia coli produtora de beta-lactamases de espectro estendido, Klebsiella pneumoniae produtora de beta-lactamases de espectro estendido e Acinetobacter baumannii multirresistente in vitro. FEMS Microbiology Letters,2021; 368(19): 138.
FEDOROV E, et al. Short-Term Outcomes of Phage-Antibiotic Combination Treatment in Adult Patients with Periprosthetic Hip Joint Infection. Viruses, 2023; 15(2): 499.
FERREIRA R, et al. Caracterização e análise genômica de um novo fago infectando Helicobacter pylori. International journal of molecular sciences, 2022; 23(14): 7885.
GREEN SI, et al. A retrospective, observational study of 12 cases of expanded-access customized phage therapy: Production, characteristics, and clinical outcomes. Clin Infect Dis, 2023; 77(8): 1079-1091.
KAŹMIERCZAK N, et al. Comparative assessment of bacteriophage and antibiotic activity against multidrug-resistant Staphylococcus aureus biofilms. International Journal of Molecular Sciences, 2022; 23(3): 1274.
KEBRIAEI R, et al. Optimization of Phage-Antibiotic Combinations against Staphylococcus aureus Biofilms. Microbiology spectrum, 2023; 11(3): 491822.
LE T, et al. Therapeutic Potential of Intravenous Phage as Standalone Therapy for Recurrent Drug-Resistant Urinary Tract Infections. Antimicrobial agents and chemotherapy, 2023; 67(4): 3723.
LEITNER L, et al. Intravesical bacteriophages for treating urinary tract infections in patients undergoing transurethral resection of the prostate: a randomised, placebo-controlled, double-blind clinical trial. The Lancet infected diseases, 2020; 21(3): 427-436.
LI C, et al. Thermosensitive hydrogel wound dressing loaded with bacteriophage lysin LysP53. Viruses, 2022; 14(9): 1956.
MENCKE JL, et al. Identificação e caracterização de vB_PreP_EPr2, um bacteriófago lítico de Providencia rettgeri pan-resistente a medicamentos. Viruses, 2022; 14(4): 708.
MOHAMMADI M, et al. Isolation, characterization, therapeutic potency, and genomic analysis of a novel bacteriophage vB_KshKPC-M against carbapenemase-producing Klebsiella pneumoniae strains (CRKP) isolated from Ventilator-associated pneumoniae (VAP) infection of COVID-19 patients. Annals of clinical microbiology and antimicrobials, 2023; 22(1): 18.
NIKOLIC I, et al. Um método de tabuleiro de xadrez otimizado para detecção de sinergia de fago-antibiótico. Viruses, 2022, 14(7): 1542.
OMS. WHO Report on Surveillance of Antibiotic Consumption. 2019. Disponível em: https ://www.who.int/publications/i/item/who-report-on-surveillance-of-antibiotic-consumption. Acesso em: 29 de novembro de 2024.
ONALLAH H, et al. Refractory Pseudomonas aeruginosa infections treated with phage PASA16: A compassionate use case series. Med (NY), 2023; 4(9): 600-611.
O'NEILL J. Antimicrobial resistance: tackling a crisis for the health and wealth of nations. The Review on Antimicrobial Resistance, 2014; 20.
RACENIS K, et al. Successful Bacteriophage-Antibiotic Combination Therapy against Multidrug-Resistant Pseudomonas aeruginosa Left Ventricular Assist Device Driveline Infection. Viruses, 2023; 15(5): 1210.
REIS AC, et al. Biodegradation of antibiotics: The new resistance determinants - part I. New Biotechnology, 2020; 54: 34-51.
TORTORA GJ, et al. Microbiologia, Porto Alegre: ArtMed, 2017; 12: 278-575.
WANG X, et al. Isolation and characterization of three Pseudomonas aeruginosa viruses with therapeutic potential. Microbiol Spectr, 2023; 11(3).
WINTACHAI P et al. Isolamento e caracterização de um novo fago Autographiviridae e seu efeito combinado com tigeciclina no controle de infecções de pele e tecidos moles associadas a Acinetobacter baumannii multirresistentes. Viruses, 2022; 14(2): 194.
ZHAO M, et al. Engineered phage with cell-penetrating peptides for intracellular bacterial infections. mSystems, 2023; 8(5): 646-23.