Abstract
Objective: To describe the main factors related to the Pediatric Multisystem Inflammatory Syndrome Associated with Covid-19 (SIM-P) and its complications in the current scenario, as well as its main differences with Kawazaki Disease (KD). Bibliographic review: The research was carried out in an exploratory way in the context of current events, and in the scientific opinions found today about the main clinical manifestations of SIM-P, which are: hyperthermia, abdominal symptoms, cutaneous manifestations, generalized lymphadenopathy, cardiac and nervous alterations and the manifestations from DK. Final considerations: Despite the limited scientific evidence available, it is believed that there is childhood inflammation that may be associated with SARS-CoV-2 infection, similar to Kawasaki disease. Complete clinical examination, including anamnesis, physical examination, epidemiological link and suspected or confirmed cases of Covid-19 in the last 2 to 4 weeks, in addition to the request of complementary tests to evaluate the inflammatory process and organ involvement, is essential for suspected diagnosis and treatment.
References
ALONSO IAF, et al. Doenças cardiovasculares em crianças com síndrome inflamatória multissistêmica decorrente de infecção por covid-19: uma revisão integrativa. Brazilian Journal of Development, 2021; 7(7): 66327-66341.
BORDET J, et al. Paediatric multisystem inflammatory syndrome associated with COVID-19: filling the gap between myocarditis and Kawasaki?. European journal of pediatrics, 2020; 180(3): 877-884.
CAMPOS LR, et al. Síndrome inflamatória multissistêmica pediátrica (MIS-C) temporariamente associada ao SARS-CoV-2. Resid Pediatr. ,2020; 10(2): 1-6.
CATTALINI M, et al. Defining Kawasaki disease and pediatric inflammatory multisystem syndrometemporally associated to SARS-CoV-2 infection during SARS-CoV-2 epidemic in Italy: results from a national, multicenter survey. Pediatr Rheumatol Online J. , 2021; 19(1): 29.
CHEN N, et al. Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study. Lancet, 2020; 395(10223): 507-513.
DAVIES P, et al. Intensive care admissions of children with paediatric inflammatory multisystem symdrome temporally associated with SARS-CoV-2 (PIMS-TS) in the UK: a multicentre observational study. Lancet Child Adolesc Health, 2020; 20: 30215-30217.
DONG Y, et al. Epidemiology of COVID-19 among children in china. Pediatrics, 2020; 145(6): e20200702.
FELDSTEIN LR, et al. Multisystem inflammatory Syndrome in U.S. Children and adolescentes. N Engl J Med, 2020; 383(4): 334-346.
GODFRED-CATO S, et al. COVID-19- Associated Multisystem Inflammatory Syndrome in Children – United States, MarchJuly 2020. Morbidity and Mortality Weekly Report (MMWR), 2020; 69(32): 1074-1080.
HAN Q, et al. Coronavirus 2019-nCoV: A brief perspective from the front line. J Infect., 2020; 80(4): 373-377.
HILLESHEIM D, et al. Síndrome respiratória aguda grave por COVID-19 em crianças e adolescentes no Brasil: perfil dos óbitos e letalidade hospitalar até a 38a Semana Epidemiológica de 2020. Epidemiol. Serv. Saúde, 2020; 29(5): e2020644.
HOANG A. et al. COVID-19 in 7780 pediatric patients: a systematic review. Eclinical Medicine, 2020; 24: 1-19.
KABEERDOSS J, et al. Severe COVID19, multisystem inflammatory syndrome in children, and Kawasaki disease: immunological mechanisms, clinical manifestations and management. Rheumatology International, 2020; 41: 19.
SARZAEIM M, REZAEI N. Kawasaki Disease and Multisystem Inflammatory Syndrome in Children with COVID-19. SN Comprehensive Clinical Medicine, 2020; 2: 2096.
SWANN OV, et al. Clinical characteristics of children and young people admitted to hospital with covid-19 in United Kingdom:prospective multicentre observational cohort study. BMJ, 2020; 370: 3249.
VIEIRA RSR, et al. Clinical Characteristics in Children and Adolescents with SARS-CoV-2 Infection: Experience in a highly complex Public Hospital in the city of Sao Paulo. MedRXiV, 2020.
WANG Y, et al. Children hospitalized with Severe COVID-19 in Wuhan. Pediatr Infect Dis J., 2020; 39(7): 91–94.
ZHENG F, et al. Clinical Characteristics of Children with Coronavirus Disease 2019 in Hubei, China. Curr Med Sci., 2020; 40(2): 275-280.
