Keywords
Mental disorders
Drug therapy
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Abstract
Objective: To analyze the therapeutic approaches of Medicinal Cannabis (MC) and evaluate its contribution to improving the quality of life of patients with psychiatric disorders. Methods: The methodological part is formed by the National Library of Medicine, Virtual Health Library and Directory of Open Access Journals, which were the databases used to form the bibliographic compilation of this literature review. The descriptors used were “Medical Marijuana”, “Mental Disorders” and “Drug Therapy. Inclusion criteria were articles from clinical trials, randomized or non-randomized, case-control studies, cohort study, free access, published in English, Portuguese, Spanish and between 2017 and 2022. Results: The eleven selected articles were The results were evaluated and a comparative table was constructed, which is composed of the number of individuals addressed in the studies, year of publication and the substance used for the treatment of psychiatric disorder according to the age addressed. Final considerations: Thus, the most used substance is the combination of Delta-9-Tetrahydrocannabinol and Cannabidiol for chronic pain, addiction related to alcoholism, obsessive-compulsive disorder, chronic insomnia, post-traumatic stress disorder, depression, epilepsy and dystonia with motor complex in patients aged 35.5 years.
References
ABRAMS DI, et al. Efeito da Cannabis Inalada para Dor em Adultos com Doença Falciforme. JAMA Netw Open, 2020; 3(7): e2010874.
ARAÚJO ÁC, NETO FL. A nova classificação americana para os transtornos mentais: o DMS-5. Jornal de Psicanálise, 2013; 46(85): 99–116.
AVIRAM J, et al. Efficacy of cannabis-based medicines for pain management: a systematic review and meta-analysis of randomized controlled trials. Pain Physician, 2017; 20(6): E755-96.
BELLNIER T, et al. Preliminary evaluation of the efficacy, safety, and costs associated with the treatment of chronic pain with medical cannabis. Ment Health Clin, 2018; 8(3) :110-5
BONN-MILLER MO, et al. O impacto a curto prazo de 3 preparações de cannabis fumadas versus placebo nos sintomas de TEPT: um ensaio clínico cruzado randomizado. PLoS One, 2021; 16(3): e0246990.
COMPTON WM, et al. Use of marijuana for medical purposes among adults in the United States. JAMA, 2017; 317: 209–211.
CROWLEY K, et al. Self-reported effectiveness and safety of Trokie(r) lozenges: a standardized formulation for the buccal delivery of cannabis extracts. Front Neurosci, 2018; 12: 564.
DUVALL SW, et al. Implicações éticas para provedores sobre o uso de cannabis em crianças com transtornos do espectro do autismo. Pediatria, 2019; 143(2): e20180558.
HÄUSER W, et al. Efficacy, tolerability and safety of cannabis-based medicines for chronic pain management: an overview of systematic reviews. Eur J Pain, 2018; 22(3): 455-70.
HUNT H, et al. An introduction to overviews of reviews: planning a relevant research question and objective for an overview. Syst Rev, 2018; 7(1): 39.
JÚNIOR FJGS, MONTEIRO CFS. Uso de álcool e outras drogas e sofrimento mental no universo feminino. Rev Bras Enferm, 2020; 73(1): e20180268.
KAYSER RR, et al. Efeitos agudos dos canabinóides nos sintomas do transtorno obsessivo-compulsivo: um estudo de laboratório humano. Depress Anxiety, 2020; 37(8): 801–811.
KOREN G, et al. Uso de Cannabis no Transtorno do Espectro Alcoólico Fetal. Cannabis Cannabinoid Res, 2021; 6(1): 74–76.
LEWEKE FM, et al. O canabidiol aumenta a sinalização da anandamida e alivia os sintomas psicóticos da esquizofrenia. Transl Psychiatry, 2012; 2(3): e94.
LIBZON S, et al. Cannabis Medicinal para Transtornos Motores Complexos Moderados a Graves Pediátricos. J Child Neurol, 2018; 33(9): 565–571.
MECHOULAM R. Endocanabinóides e transtornos psiquiátricos: a estrada à frente. Rev Bras Psiquiatr, 2010; 32(1): 55–56.
MÜCKE M, et al. Cannabis-based medicines for chronic neuropathic pain in adults. Cochrane Database Syst Rev, 2018; 3(3): CD012182
PEREIRA CF, et al. Implicações do uso de cannabis e canabinóides no COVID-19: revisão de escopo. Rev Bras Enferm, 2022; 75(1): e20201374.
POGHOSYAN H, et al. Associação entre uso diário e não diário de cannabis e depressão entre sobreviventes adultos de câncer nos Estados Unidos. Nurs Outlook, 2021; 672–685.
PUTEIKIS K, MAMENIŠKIENĖ R. Uso de cannabis e seus produtos entre pacientes em um centro de epilepsia terciário: Uma pesquisa transversal. Epilepsy Behav, 2020; 111.
SANTOS AG, MONTEIRO CFS. Domínios dos transtornos mentais comuns em mulheres que denunciam violência por parceiro íntimo. Rev Latino-Am Enfermagem, 2018; 26(0).
SILVA RG, et al. Uma revisão baseada na análise Canabino da crônica: uma revisão baseada na análise Canabino. Revista Portuguesa de Medicina Geral e Familiar, 2021; 37(2): 133–144.
SOHLER NL, et al. O uso de cannabis está associado a menores chances de uso de analgésicos opióides prescritos entre indivíduos infectados pelo HIV com dor crônica. Subst Use Misuse, 2018; 53(10): 1602–1607.
STOCKINGS E, et al. Cannabis and cannabinoids for the treatment of people with chronic noncancer pain conditions: a systematic review and meta-analysis of controlled and observational studies. Pain, 2018; 159(10): 1932-54.
SUBBARAMAN MS, et al. O uso de cannabis durante o tratamento com álcool está associado a problemas relacionados ao álcool um ano após o tratamento. Drug Alcohol Depend, 2018; 193: 29–34.
TREEDE RD, et al. Chronic pain as a symptom or a disease: the IASP Classification of Chronic Pain for the International Classification of Diseases (ICD-11). Pain, 2019; 160(1): 19-27.
VRIES M, et al. Tetrahydrocannabinol does not reduce pain in patients with chronic abdominal pain in a phase 2 placebo-controlled study. Clin Gastroenterol Hepatol, 2017; 15(7): 1079-86.e4.
WAGNER MF, et al. Níveis de impulsividade em indivíduos com transtorno por uso de cannabis. Trends Psychiatry Psychother, 2022; 44.
WALSH JH, et al. Tratando sintomas de insônia com cannabis medicinal: um estudo randomizado e cruzado da eficácia de um medicamento canabinóide em comparação com placebo. Dormir, 2021; 44(11): zsab149.
WEIZMAN L, et al. Cannabis analgesia in chronic neuropathic pain is associated with altered brain connectivity. Neurology, 2018; 91(14): e1285-94.