Supplementary Files
Keywords
Autoimmune diseases
Causality
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Abstract
Objective: To present a brief introduction about Systemic Lupus Erythematosus (SLE) and discuss the factors that predispose the disease activity in an updated way. Bibliographic review: SLE is an autoimmune disease of diverse presentation, diagnosed by a combination of clinical and laboratory signs. Among the predisposing factors, immunogenetics are the best known. In addition to genetic factors, viral infections, stress, sun exposure and even pregnancy can trigger the activation of the disease. The most affected population is women, with hormonal causes being the most accepted explanation. Management of the activity consists of the use of corticosteroids and anti-inflammatory drugs. Final considerations: Lupus is an autoimmune disease, with no curative treatment. There is a constant relationship between the manifestation of the disease and genetic and hormonal characteristics, and its activity is most commonly linked to infections, sun exposure and the use of certain medications. Further studies addressing predisposing factors in larger populations are needed.
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