Palavras-chave
Depressão
Transtorno depressivo resistente a tratamento
Como Citar
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Resumo
Objetivo: Analisar as repercussões dos metabólitos glutamatérgicos na depressão, elucidando a relação entre os níveis de glutamato e a sintomatologia apresentada pelos pacientes. Métodos: Revisão integrativa da literatura realizada nas bases PubMed e Biblioteca Virtual em Saúde, utilizando os descritores “glutamic acid” e “depression”, associados pelo operador booleano “AND”. Foram selecionados artigos publicados entre 2017 e 2025, incluindo estudos clínicos, ensaios clínicos, estudos comparativos, ensaios clínicos controlados, estudos observacionais e ensaios controlados randomizados. Foram excluídos estudos com texto completo indisponível, artigos duplicados, trabalhos com tema divergente dos objetivos e estudos realizados em animais. A amostra final consistiu em 24 artigos. Resultados: Os estudos analisados evidenciaram que não há consenso definitivo sobre o papel dos metabólitos glutamatérgicos na depressão, embora diversas pesquisas apontem melhora clínica associada à modulação dos níveis de glutamato. A via glutamatérgica surge como potencial alvo terapêutico, especialmente em casos de transtornos depressivos resistentes ao tratamento convencional. Considerações finais: A exploração de novas investigações sobre a via glutamatérgica é relevante para consolidar alternativas terapêuticas, contribuindo para o suporte clínico a pacientes acometidos por depressão, visando melhor qualidade de vida e eficácia terapêutica.
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