Palavras-chave
Tabagismo
Câncer de pulmão
Como Citar
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Resumo
Objetivo: Analisar as evidências científicas acerca da relação entre o uso de dispositivos eletrônicos para fumar e os mecanismos biológicos associados ao risco de câncer de pulmão. Métodos: Trata-se de revisão integrativa da literatura, estruturada conforme as recomendações do PRISMA e fundamentada na estratégia PICO. A busca bibliográfica foi realizada na base PubMed utilizando os descritores Electronic Nicotine Delivery Systems, Smoking e Lung Neoplasms, combinados por operadores booleanos. Foram incluídos estudos publicados entre 2020 e 2025, totalizando nove artigos na amostra final. Resultados: Os estudos analisados demonstraram que a exposição aos aerossóis dos dispositivos eletrônicos pode induzir estresse oxidativo, inflamação crônica, alterações epigenéticas, dano ao DNA, disfunção imunológica e alterações proliferativas compatíveis com mecanismos envolvidos na carcinogênese pulmonar. Evidências experimentais também identificaram potencial de promoção tumoral e comprometimento da homeostase respiratória. Considerações finais: Embora as evidências atuais ainda não permitam estabelecer relação causal definitiva entre o uso exclusivo desses dispositivos e o aumento da incidência de câncer de pulmão, os dispositivos eletrônicos para fumar não são biologicamente inertes, reforçando a necessidade de estudos longitudinais e medidas regulatórias em saúde pública.
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