Supplementary Files
Keywords
Postoperative period
Prevention of diseases
Operative surgical procedures
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Abstract
Objective: To investigate possible ways to prevent delirium in the postoperative period. Methods: An integrative literature review was conducted with a qualitative approach, based on the National Library of Medicine (PubMed) and the Virtual Health Library (BVS), with articles published between 2016 and 2021, available completely free of charge in electronic media and studies of the type clinical trials, randomized or non-randomised, case-control studies and cohort studies. Results: Drugs already known in the hospital environment were used, with different dosages and forms of administration, and non-drug strategies in an attempt to avoid the emergence of delirium. Among the selected articles, 44% were successful in preventing postoperative delirium due to the interaction of the drugs used that acted in the pathophysiology of this disease. Final considerations: The study showed that it is possible to reduce the incidence of postoperative delirium with certain drugs and, consequently, prevent this pathology, however, it has limitations to standardize this treatment.
References
Al TMIMI L, et al. Intraoperative xenon for prevention of delirium after on-pump cardiac surgery: a randomised, observer-blind, controlled clinical trial. Br J Anaesth., 2020; S0007-0912(19): 31025-6.
AVIDAN MS, et al. Intraoperative ketamine for prevention of postoperative delirium or pain after major surgery in older adults: an international, multicentre, double-blind, randomised clinical trial. Lancet, 2017; 390(10091): 267-275.
AZEEM TMA, et al. Dexmedetomidine vs morphine and midazolam in the prevention and treatment of delirium after adult cardiac surgery; a randomized, double-blinded clinical trial.Saudi J Anaesth 2018; 12(2): 190-197.
COBURN M, et al. The hip fracture surgery in elderly patients (HIPELD) study to evaluate xenon anaesthesia for the prevention of postoperative delirium: a multicentre, randomized clinical trial. Br J Anaesth., 2018; 120(1): 127-137.
DEINER S, et al. Intraoperative Infusion of Dexmedetomidine for Prevention of Postoperative Delirium and Cognitive Dysfunction in Elderly Patients Undergoing Major Elective Noncardiac Surgery: A Randomized Clinical Trial. JAMA Surg., 2017; 152(8): 171505.
FITZPATRICK S e OWEN K. Transtornos Cognitivos Pós-Operatórios: Delirium Pós-Operatório e Disfunção Cognitiva Pós-Operatória. Anesthesia tutorial of the week, 2018; 385: 2-6.
GAO F, et al. Transcutaneous electrical acupoint stimulation for prevention of postoperative delirium in geriatric patients with silent lacunar infarction: a preliminary study. Clin Interv Aging, 2018; 13: 2127-2134.
HE X, et al. Dexmedetomidine for the prevention of postoperative delirium in patients after intracranial operation for brain tumours (DEPOD study): a study protocol and statistical plan for a multicentre randomised controlled trial. BMJ Open, 2020; 10(11): 040939.
HOLLINGER A, et al. Ketamine vs. haloperidol for prevention of cognitive dysfunction and postoperative delirium: A phase IV multicentre randomised placebo-controlled double-blind clinical trial. J Clin Anesth 2021; 68: 110099.
JAISWAL SJ, et al. Ramelteon for Prevention of Postoperative Delirium: A Randomized Controlled Trial in Patients Undergoing Elective Pulmonary Thromboendarterectomy. Crit Care Med., 2019; 47(12): 1751-1758.
JANSSEN TL, et al. Multimodal prehabilitation to reduce the incidence of delirium and other adverse events in elderly patients undergoing elective major abdominal surgery: An uncontrolled before-and-after study. PLoS One, 2019; 14(6): 0218152.
JAVAHERFOROOSH Zadeh F, et al. Effect of Melatonin on Delirium After on-Pump Coronary Artery Bypass Graft Surgery: A Randomized Clinical Trial. Iran J Med Sci, 2021; 46(2): 120-127.
JIN L, et al. Ultrasound-guided continuous thoracic paravertebral block alleviates postoperative delirium in elderly patients undergoing esophagectomy: A randomized controlled trial. Medicine (Baltimore), 2020; 99(17): 19896-19896.
KHERA T, et al. Scheduled Prophylactic 6-Hourly IV AcetaminopheN to Prevent Postoperative Delirium in Older CaRdiac SurgicAl Patients (PANDORA): protocol for a multicentre randomised controlled trial. BMJ Open, 2021; 11(3): 044346.
LIKHVANTSEV VV, et al.Perioperative Dexmedetomidine Supplement Decreases Delirium Incidence After Adult Cardiac Surgery: A Randomized, Double-Blind, Controlled Study. J Cardiothorac Vasc Anesth., 2021; 35(2): 449-457.
MOSLEMI R, et al. Thiamine for Prevention of Postoperative Delirium in Patients Undergoing Gastrointestinal Surgery: A Randomized Clinical Trial. J Res Pharm Pract., 2020; 9(1): 30-35.
OH SC, et al. Effect of deep neuromuscular blockade on serum cytokines and postoperative delirium in elderly patients undergoing total hip replacement: A prospective single-blind randomised controlled trial. Eur J Anaesthesiol., 2021; 38(Suppl 1): S58-S66.
OMICHI C, et al. Association between discontinuation of benzodiazepine receptor agonists and post-operative delirium among inpatients with liaison intervention: A retrospective cohort study.Compr Psychiatry, 2021; 104: 152216.
SPIES C, et al. Physostigmine for prevention of postoperative delirium and long-term cognitive dysfunction in liver surgery: A double-blinded randomised controlled trial. Eur J Anaesthesiol., 2021; 38(9): 943-956.
SUSHEELA AT, et al. The use of dexmedetomidine and intravenous acetaminophen for the prevention of postoperative delirium in cardiac surgery patients over 60 years of age: a pilot study. F1000Res., 2017; 6(2): 1842.
SU X, et al. Dexmedetomidine for prevention of delirium in elderly patients after non-cardiac surgery: a randomised, double-blind, placebo-controlled trial. Lancet, 2016; 388(10054): 1893-1902.
TURAN A, et al. Dexmedetomidine for reduction of atrial fibrillation and delirium after cardiac surgery (DECADE): a randomised placebo-controlled trial. Lancet, 2020; 396(10245): 177-185.
UYSAL AI, et al. The effects of early femoral nerve block intervention on preoperative pain management and incidence of postoperative delirium geriatric patients undergoing trochanteric femur fracture surgery: A randomized controlled trial. Ulus Travma Acil Cerrahi Derg, 2020; 26(1): 109-114.
VLISIDES PE, et al. Perioperative Epidural Use and Risk of Delirium in Surgical Patients: A Secondary Analysis of the PODCAST Trial.Anesth Analg, 2019; 128(5): 944-952.
WADA S, et al. Yokukansan for perioperative psychiatric symptoms in cancer patients undergoing high invasive surgery. J-SUPPORT 1605 (ProD Study): study protocol for a randomized controlled trial. Trials, 2019; 20(1): 110-110.
XIN X, et al. Hypertonic saline for prevention of delirium in geriatric patients who underwent hip surgery. J Neuroinflammation, 2017; 14(1): 221-221.