Keywords
Autoimmune diseases
Gastroenterology
How to Cite
Copyright © | All rights reserved.
The journal holds the exclusive copyright for the publication of this article under the terms of Brazilian law 9610/98.
Partial reproduction
The use of parts of the texts, figures and questionnaire of the article is free, being mandatory the citation of the authors and journal.
Total reproduction
It is expressly prohibited and must be authorized by the journal.
Abstract
Objective: Examine the characteristics of Celiac Disease (CD). Bibliographic review: CD is an autoimmune disease triggered by the ingestion of gluten protein by genetically susceptible individuals. The main manifestations are gastrointestinal symptoms such as diarrhea, abdominal pain, nausea, vomiting and chronic constipation. Chronic fatigue, deficiency anemia and neuropsychiatric symptoms are also common. Diagnosis should be made as early as possible to improve the quality of life of celiac patients and prevent complications. The effective treatment is the total elimination of gluten from the diet. There are other therapies, but they are used in cases of accidental ingestion of gluten. Final considerations: It is concluded that untreated CD causes great harm to the quality of life of patients and can lead to serious complications. It is extremely important that the diagnosis is made early and that the total elimination of gluten is implemented as soon as possible. In addition, psychological support and specialized nutritional monitoring are essential to promote adherence to the diet and improve the emotional well-being of individuals living with celiac disease.
References
ABOULAGHRAS S, et al. Pathophysiology and immunogenetics of celiac disease. Clin Chim Acta. 2022; 528: 74-83.
ALJADA B, et al. The Gluten-Free Diet for Celiac Disease and Beyond. Nutrients. 2021; 13(11): 3993.
ALKHIARI R. Psychiatric and Neurological Manifestations of Celiac Disease in Adults. Cureus. 2023; 15(3): 35712.
AL-TOMA A, et al. European Society for the Study of Coeliac Disease (ESsCD) guideline for coeliac disease and other gluten-related disorders. United European Gastroenterol J. 2019; 7(5): 583-613.
BESSER HA, KHOSLA C. Celiac disease: mechanisms and emerging therapeutics. Trends Pharmacol Sci. 2023; 44(12): 949-962.
CAIO G, et al. Celiac disease: a comprehensive current review. BMC Med. 2019; 17(1): 142.
DIECKMAN T, et al. Celiac disease: New therapies on the horizon. Curr Opin Pharmacol. 2022; 66: 102268.
HUJOEL IA, et al. Celiac Disease: Clinical Features and Diagnosis. Gastroenterol Clin North Am. 2019; 48(1): 19-37.
LEBWOHL B, RUBIO-TAPIA A. Epidemiology, Presentation, and Diagnosis of Celiac Disease. Gastroenterology. 2021; 160(1): 63-75.
MACHADO MV. New Developments in Celiac Disease Treatment. Int J Mol Sci. 2023; 24(2): 945.
MASUCCI L, et al. Celiac Disease Predisposition and Genital Tract Microbiota in Women Affected by Recurrent Pregnancy Loss. Nutrients. 2023; 15(1): 221.
MONTORO-HUGUET MA, et al. Iron Deficiency in Celiac Disease: Prevalence, Health Impact, and Clinical Management. Nutrients. 2021; 13(10): 3437.
RUBIO-TAPIA A, et al. American College of Gastroenterology Guidelines Update: Diagnosis and Management of Celiac Disease. Am J Gastroenterol. 2023; 118(1): 59-76.
TALARICO V, et al. Iron Deficiency Anemia in Celiac Disease. Nutrients. 2021 May 17; 13(5): 1695.
THERRIEN A, et al. Celiac Disease: Extraintestinal Manifestations and Associated Conditions. J Clin Gastroenterol. 2020; 54(1): 8-21.
WU X, et al. Gastrointestinal microbiome and gluten in celiac disease. Ann Med. 2021 (1): 1797-1805.
ZIGONE F, et al. Celiac Disease-Related Conditions: Who to Test? Gastroenterology. 2024; 167(1): 64-78.