Palabras clave
Clopidogrel
Infarto del miocardio
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Resumen
Objetivo: Evaluar la efectividad del clopidogrel frente a otros antiagregantes plaquetarios, demostrando su uso en diferentes poblaciones y su asociación con la mortalidad. Métodos: Las búsquedas se realizaron en las bases de datos PubMed y Biblioteca Virtual en Salud (BVS) e incluyeron estudios publicados entre 2018-2023, ensayos clínicos controlados, estudios observacionales, textos completos y gratuitos y artículos fuera de tema y duplicados excluidos. Resultados: Se incluyeron 25 artículos para la síntesis narrativa, donde a través del análisis de los estudios se observó que el clopidogrel, a pesar de no ser el antiagregante plaquetario más recomendado actualmente, es el más utilizado por los costos económicos y su confiabilidad en su uso, y que factores como la edad mayor de 75 años, las interacciones medicamentosas y el consumo crónico de drogas presentan resultados favorables. Consideraciones finales: Se puede considerar que el uso de clopidogrel en el infarto agudo de miocardio con elevación del ST presenta cierta desventaja en comparación con otros antiagregantes plaquetarios, sin embargo, su uso está descrito de manera confiable y considerado un buen inhibidor del receptor P2Y12. Los presentes estudios no pudieron demostrar de manera confiable su superioridad o inferioridad en comparación con otros medicamentos, ya que la población, la cultura y los países eran diferentes.
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