Palabras clave
Inhibidores del transportador de sodio-glucosa 2
Insuficiencia cardíaca
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Resumen
Objetivo: Analizar la evidencia disponible sobre la eficacia de los inhibidores de SGLT2 en la prevención de la insuficiencia cardíaca en adultos con diabetes mellitus tipo 2. Métodos: Se trata de una revisión integradora de la literatura realizada a través de las bases de datos PubMED, Biblioteca Virtual en Salud (BVS) y Periódica CAPES, utilizando los descriptores: “Sodium-Glucose Transporter 2 Inhibitors”, “Prevention”, “Adults” y “Heart Failure” y obteniendo el truncamiento de búsqueda: (Sodium-Glucose Transporter 2 Inhibitors) AND (Prevention) AND (Heart Failure) AND (Adults). Se encontraron 367 artículos, filtrados según criterios de inclusión (portugués, inglés y español; período de 2020 a 2025; artículos completos) y criterios de exclusión (artículos duplicados, resúmenes, fuera de alcance). Resultados: Los inhibidores de SGLT2 previenen eficazmente la insuficiencia cardíaca en diabéticos tipo 2 a través de múltiples mecanismos cardioprotectores que van más allá del control glucémico, como la natriuresis y la mejoría hemodinámica. Consideraciones finales: La respuesta al tratamiento y la magnitud de los beneficios, incluida la protección renal y cognitiva, están influenciados por las características del paciente, lo que refuerza su uso estratégico y temprano.
Referencias
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