Palavras-chave
terapia fágica
peptídeos antimicrobianos
compostos organometálicos
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Resumo
Objetivo: Abordar o desafio global em saúde pública e as alternativas que estão sendo desenvolvidas no combate a resistência antimicrobiana. Revisão bibliográfica: A crescente resistência antimicrobiana é um desafio global em saúde pública que está associada a um alto número de mortes anuais e ameaça superar o câncer como a principal causa de mortalidade até 2050. Ainda, o desenvolvimento de novos antimicrobianos enfrenta obstáculos significativos incluindo o alto custo, incerteza de mercado e falta de interesse da indústria farmacêutica. Buscando atenuar esse cenário, novas alternativas antimicrobianas estão sendo desenvolvidas e demonstram resultados promissores. A terapia fágica utiliza bacteriófagos para infectar bactérias, os peptídeos antimicrobianos são moléculas de aminoácidos com ação direta ou imunomoduladora, e os compostos organometâlicos são redes de coordenação de metais e ligantes orgânicos com propriedades antimicrobianas. Considerações finais: Cada uma das alternativas descritas no apresenta vantagens e desafios, mas todas oferecem esperança no desenvolvimento de novos antimicrobianos eficazes. A resistência antimicrobiana representa uma ameaça à saúde pública global e exige a busca por soluções inovadoras para garantir o sucesso contínuo da medicina moderna.
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