Keywords
Capsicum spp.
Neuropathic pain
How to Cite
Copyright © | All rights reserved.
The journal holds the exclusive copyright for the publication of this article under the terms of Brazilian law 9610/98.
Partial reproduction
The use of parts of the texts, figures and questionnaire of the article is free, being mandatory the citation of the authors and journal.
Total reproduction
It is expressly prohibited and must be authorized by the journal.
Abstract
Objective: To gather, synthesize, and compare publications in the literature addressing the potential of species from the genus Capsicum spp. in neuropathic pain control. Methods: This is an integrative literature review, with a qualitative approach, conducted through searches in online databases: PubMed, Scielo, and Lilacs. The search used the following descriptors: pain, neuropathic, capsicum, analgesia, in both English and Portuguese languages, alone and combined, using the boolean operator "and". Inclusion criteria comprised original articles, systematic reviews, articles published in journals, books, and master's dissertations, with full-text and open access, published between 2020 and 2024, focusing on the use of Capsicum L. and its applicability in neuropathic pain treatment. Exclusion criteria included conference abstracts, proceedings, articles behind paywalls, and publications unavailable in full. Results: Thirty-three articles were selected, all in English. Among these, only eight met the inclusion criteria. All analyzed articles demonstrated some effect of Capsicum spp. in neuropathic pain through capsaicin action, covering its molecular mechanism and comparison with traditional therapies. Final considerations: The use of capsaicin shows promise, as recent studies have demonstrated its effectiveness, but further research in this area is warranted.
References
ABDEL-SALAM OM e MÓZSIK G. Capsaicin, The Vanilloid Receptor TRPV1 Agonist in Neuroprotection: Mechanisms Involved and Significance. Neurochem Res 48, 3296–3315 (2023).
ALCÁNTARA A e VASCONCELOS SR. Abordaje farmacológico del dolor neuropático: pasado, presente y futuro [Pharmacological approach to neuropathic pain: past, present and future]. Revista de neurología, 2022, 74(8), 269–2
BARKER C e ELSTON DM. Botanical Briefs: Handling the Heat From Capsicum Peppers. Cutis, 2022, 111(5), 241–243.
BATIHA GE, et al. “Biological Properties, Bioactive Constituents, and Pharmacokinetics of Some Capsicum spp. and Capsaicinoids.” International journal of molecular sciences 2020, 21(15): 5179.
BEAR M F. Neurociências. 4 ed. Porto Alegre: Editora Artmed, 2017.
BONEZZI C, et al. Adesivo dérmico de capsaicina 8% na prática clínica: opinião de especialistas. Opinião de Especialistas em Farmacoterapia, 2020, 21 (11), 1377–1387.
CATALFAMO et al. A utilidade do Capsicum annuum L. na medicina interna e na odontologia: uma revisão abrangente. Revista Internacional de Pesquisa Ambiental e Saúde Pública, 2022; 18: 11187.
CHANG A et al. Capsaicin. StatPearls, 2023. PMID: 29083760.
DURAN P e KHANNA R. Some Like It Hot: Dynamic Control of Cav2.2 Channels By Chili Peppers. Function (Oxford, England)2022; 4(1) .
FINNERUP NB, et al. Neuropathic Pain: From Mechanisms to Treatment. Physiological Reviews, v. 101, n. 1, p. 259–301, 1 jan. 2021.
FIUSA MF, et al. Protocolos de reabilitação na dor neuropática: uma revisão bibliométrica. BrJP. São Paulo, 2023 out-dez;6(4):448-53.
GRANDISOLLI, et al. Creme analgésico à base de capsicum annum e outros extratos vegetais. Revista Multidisciplinar da Saúde (RMS), 2022; 04(3): 100 - 140.
HALL OM, et al. Novel Agents in Neuropathic Pain, the Role of Capsaicin: Pharmacology, Efficacy, Side Effects, Different Preparations. Curr Pain Headache Rep 24, 53 (2020).
JANG HH, et al. Effects of Capsicum annuum supplementation on the components of metabolic syndrome: a systematic review and meta-analysis. Sci Rep 10, 20912 (2020).
KAUR H, et al. Catastrophic health expenditure in patients with Guillain Barre syndrome: Retrospective study. Acta Neurol Scand. 2022;145:73-78.
MELO FILHO CG, et al. A eficácia dos tratamentos para a dor neuropática. Research, Society and Development, 2022, 11(10): e17111032248-e17111032248.
REINERT JP, et al. Tricyclic Antidepressants in Nociceptive and Neuropathic Pain: A Review of Their Analgesic Properties in Combination With Opioids. The Journal of pharmacy technology, 2023. Association of Pharmacy Technicians, 39(1), 35–40.
SZEWCZYK A, et al. Neuropathic pain and chronic pain as an underestimated interdisciplinary problem. International Journal of Occupational Medicine and Environmental Health, 4 jan. 2022.
Wang F, et al. Extraction, purification, bioactivity and pharmacological effects of capsaicin: a review. Critical reviews in food science and nutrition. 2022; 62(19), 5322–5348.
ZOLEZZI DM, et al. Chronic neuropathic pain is more than a perception: Systems and methods for an integral characterization. Neuroscience & Biobehavioral Reviews, 2022, 136: 104599.