Palavras-chave
Serotonina
Ansiedade
Obesidade
Plasticidade neuronal
Como Citar
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Resumo
Objetivo: Revisar sobre os efeitos da dieta hiperlipídica e hipercalórica (DHH) materna e da inibição da recaptação da serotonina sobre peso corporal, adiposidade e regulação do comportamento. Revisão bibliográfica: A gestação e a lactação são considerados períodos críticos para o desenvolvimento do sistema nervoso dos organismos. Nesses períodos, insultos ambientais, especialmente alterações nutricionais, podem gerar modificações metabólicas, morfofuncionais e comportamentais que se expressam a longo prazo. O consumo materno de DHH também pode reduzir a disponibilidade sináptica de serotonina (5-HT), neurotransmissor que regula a expressão fenotípica de uma série de comportamentos, inclusive o comportamento emocional. Por outro lado, os inibidores seletivos da recaptação da serotonina (ISRS), aumentam a disponibilidade sináptica de 5-HT e podem atenuar as repercussões da DHH sobre o metabolismo e a expressão de comportamentos emocionais. Considerações finais: A literatura sugere que inibição da recaptação da serotonina pode atenuar os efeitos da DHH materna sobre peso corporal, adiposidade e comportamentos emocionais em prole de animais experimentais.
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