Palavras-chave
Doxiciclina
Tratamento Farmacológico
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Resumo
Objetivo: Analisar as evidências disponíveis sobre o uso da doxiciclina (DOX) como potencial agente terapêutico na Doença de Parkinson (DP), considerando seus efeitos neuroprotetores e anti-inflamatórios. Revisão bibliográfica: A DP é caracterizada pela degeneração progressiva dos neurônios dopaminérgicos, levando a sintomas motores e não motores debilitantes. Estudos indicam que a neuroinflamação tem papel crucial na progressão da doença, tornando-se um alvo terapêutico promissor. A DOX, uma tetraciclina de segunda geração, apresenta propriedades anti-inflamatórias e neuroprotetoras, além de alta lipossolubilidade e capacidade de atravessar a barreira hematoencefálica. Modelos experimentais demonstraram que a DOX reduz a degeneração neuronal, inibe a ativação da micróglia e modula a agregação de α-sinucleína, proteína associada à patogênese da DP. Esses achados sugerem que a DOX pode retardar a progressão da doença e reduzir sintomas motores e neuro inflamatórios. Considerações finais: A DOX se mostra um candidato promissor para a neuroproteção dopaminérgica, mas estudos clínicos são necessários para validar sua eficácia na DP. A reorientação desse antibiótico pode representar uma nova estratégia terapêutica para doenças neurodegenerativas.
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