Palavras-chave
Enzima convertidora de angiotensina
Mutación INDEL
Meta análisis
Como Citar
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Resumo
Objetivo: Realizamos una revisión sistemática y un metaanálisis para evaluar la asociación entre los polimorfismos en los genes ECA y ECA2 y el desarrollo de la neuropatía diabética (ND). Métodos: Se realizaron búsquedas en seis bases de datos (NCBI/PubMed, MEDLINE, Biblioteca Cochrane, Biblioteca Virtual en Salud, Scielo y Embase), así como en literatura gris (Google Scholar y citas). Dos revisores independientes seleccionaron los artículos de acuerdo con los criterios de inclusión y exclusión previamente definidos. Resultados: La búsqueda sistemática de la literatura identificó 114 registros en las bases de datos. Al finalizar la selección, se incluyeron 5 estudios en el análisis cualitativo y 4 estudios en el análisis cuantitativo. Todos los estudios incluidos fueron estudios de casos y controles realizados en poblaciones iraquí, paquistaní y turca. Conclusión: Según el metaanálisis, los genotipos ID+DD del polimorfismo I/D del gen ECA están asociados con un mayor riesgo de desarrollo de ND (OR = 1,43; IC = 1,01–2,03; p = 0,0464). Nuestro análisis también sugiere que el alelo D es un marcador de riesgo para ND (OR = 1,42; IC = 1,19–1,68; p < 0,0001), y resultados similares ya han sido reportados anteriormente. Se necesitan más estudios observacionales en diferentes poblaciones para confirmar esta asociación.
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