Palavras-chave
Teste da urease
Sorologia
Endoscopia
Amazônia brasileira
Xingu–Pará
Como Citar
Copyright © | Todos os direitos reservados.
A revista detém os direitos autorais exclusivos de publicação deste artigo nos termos da lei 9610/98.
Reprodução parcial
É livre o uso de partes do texto, figuras e questionário do artigo, sendo obrigatória a citação dos autores e revista.
Reprodução total
É expressamente proibida, devendo ser autorizada pela revista.
Resumo
Objetivo: Analisar a prevalência da infecção por Helicobacter pylori utilizando métodos sorológicos e o Teste Rápido da Urease (TUR) em adultos com queixas dispépticas, na região do Xingu. Métodos: Estudo transversal realizado entre junho e outubro de 2025, com 40 adultos (27 homens e 13 mulheres) residentes na região do Xingu e atendidos no ambulatório de cardiologia. O diagnóstico foi realizado por testes sorológicos (ELISA para IgM e IgG) e pelo TUR aplicado em biópsias gástricas obtidas durante endoscopia digestiva alta. As variáveis analisadas incluíram sexo, faixa etária, procedência e condições de saneamento básico, apresentadas em frequências absolutas e relativas. Resultados: A prevalência de H. pylori foi maior pela sorologia IgG (65%), seguida pelo TUR (40%). A IgM apresentou positividade em apenas 10%. A infecção teve maior frequência em homens, especialmente entre 40e49 anos, e em residentes da zona urbana sem acesso a água potável e esgotamento sanitário, evidenciando associação com vulnerabilidades ambientais. Conclusão: A sorologia IgG demonstrou utilidade como método não invasivo para triagem de H. pylori em regiões com recursos limitados para exames invasivos. Achados reforçam a importância de estratégias diagnósticas adaptadas ao perfil epidemiológico, marcado por saneamento precário e maior risco de exposição ao patógeno.
Referências
ALVARADO-ÁLVARE A, et al. Reduction of Helicobacter pylori cells in rural water supply using slow sand filtration. Environmental Monitoringand Assessment, 2024; 196: 619.
ALVAREZ-ARANDA J, et al. Environmental risk factors associated with Helicobacter pylori infection in rural Andean communities: a cross-sectional study. JournalofWaterand Health, 2024; 22(1): 45–58.
ARUP CONSULT. Helicobacter pylori Testing. ARUP Laboratories, 2024.
BHATTACHARYA D, et al. Determination of H. pylori prevalence by RUT in gastroenteritis patients of Raipur City of Chhattisgarh. InternationalJournalof Life Science, Biotechnologyand Pharma Research, 2025; 14(9): 1231-1234.
BOSSUYT PM, et al. STARD 2015: an updated list of essential items for reporting diagnostic accuracy studies. BMJ, 2015; 351: h5527.
BUTT J, et al. Antibody responses to Helicobacter pylori proteins predict risk of developing gastric cancer and identify individuals at high risk. Journalofthe American Heart Association, 2020; 9(18): e016000.
CASTRO-HERNANDEZ D, et al. Seroprevalence and diagnostic agreement of tests for Helicobacter pylori infection in Colombian adults from high-risk regions. Revista Colombiana de Gastroenterología, 2024; 39(2): 123–134.
CHEY WD, et al. ACG Clinical Guideline: Treatment of Helicobacter pylori Infection. American JournalofGastroenterology, 2017; 112(2): 212–239.
CROWE SE. Indications and diagnostic tests for Helicobacter pylori infection. UpToDate, 2019.
CUNHA RPA, et al. Prevalence and risk factors associated with Helicobacter pylori in native populations from Brazilian Western Amazon. Transactions of the Royal Society of Tropical Medicine and Hygiene, 2003; 97(4): 382–388.
ESCOBAR PARDM L, et al. Prevalence of Helicobacter pylori infection in native Brazilian children from the Xingu River region. Jornal de Pediatria, 2011; 87(5): 498–505.
FREITAS MA, et al. Socioenvironmental determinants of Helicobacter pylori infection in Amazonian urban populations: a multilevel approach. BrazilianJournalofInfectiousDiseases, 2023; 27: 102812.
GHAZANFAR H, et al. Advances in diagnostic modalities for Helicobacter pylori infection. Life, 2024; 14(9): 1170.
HOOI JKY, et al. Global prevalence of Helicobacter pylori infection: systematic review and meta-analysis. Gastroenterology, 2017; 153(2): 420–429.
KHEDMAT H, et al. Comparison of serology and rapid urease test in detection of Helicobacter pylori infection. Helicobacter, 2013; 18(2): 136–140.
LINS AK, et al. Infecção por Helicobacterpylori em comunidades ribeirinhas da Amazônia. Arquivos de Gastroenterologia, 2010; 47(1): 46–52.
MALFERTHEINER P, et al. Management of Helicobacter pylori infection — the Maastricht V/Florence Consensus Report. Gut, 2017; 66(1): 6–30.
MÉGRAUD F, LEHOURS P. Helicobacter pylori detection and antimicrobial susceptibility testing. Clinical Microbiology Reviews, 2007; 20(2): 280–322.
NOH CK, et al. Comparative diagnostic performance of rapid urease test with the sweeping method versus tissue sampling method after Helicobacter pylori eradication. Gastrointestinal Endoscopy, 2024; 100(4): 660–669.e3.
POLK DB, PEEK RM. Helicobacter pylori: gastric cancer and beyond. Nature Reviews Cancer, 2010; 10(6): 403–414.
RAGHUNATH P, et al. Evaluation of RUT and ELISA tests for detection of Helicobacter pylori in dyspeptic patients visiting a tertiary care hospital, South India. J Pure ApplMicrobiol, 2023; 17(1): 543–548.
RIAD MOHAMED. Association of Helicobacter pylori infection with coronary artery disease: is it an independent risk factor? Review. The Egyptian Heart Journal, 2021; 73(61): 2–6.
SANTOS JC, et al. Sex-based differences in immune response to chronic Helicobacter pylori infection: a systematic review. ImmunologyAdvances, 2023; 14(2): 199–212.
SILVA RM, et al. Serological performance of IgG, IgM and IgA antibodies for Helicobacter pylori in high-endemicity regions: a diagnostic reappraisal. Tropical GastroenterologyandHepatology, 2024; 52(1): 29–40
SHIMOYAMA T. Serological tests for the diagnosis of Helicobacter pylori infection. Clinical Journal of Gastroenterology, 2013; 6(4): 215–223.
SHUKLA P, et al. Is rapid urease test reliable as histopathological evaluation for Helicobacter pylori infection – a prospective study? Indian JournalofPathologyandOncology, 2024; 11(3): 224–228.
YU JH, et al. Evaluation of anti-Helicobacter pylori IgG antibodies for the detection of H. pylori infection in different populations. Diagnostics, 2022; 12(5): 1214.
ZAMAN A, et al. Observation of changes in Helicobacter pylori antigen and antibodies before and after therapy. InfectionandDrugResistance, 2020; 13: 2485–2492.
ZAMANI M, et al. Systematic review with meta-analysis: the worldwide prevalence of Helicobacter pylori infection. AlimentaryPharmacology&Therapeutics, 2018; 47(7): 868–876.
ZHOU L, et al. Worldwide prevalence and risk factors of Helicobacter pylori infection in children and adults: a systematic review and meta-analysis. Children, 2022; 9(9): 1359.