Palavras-chave
Biópsia líquida
HPV
Como Citar
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Resumo
Objetivo: Avaliar a capacidade preditiva de um exame de urina em pacientes com patologias vulvares, vaginais e cervicais induzidas pelo HPV. Métodos: Estudo prospectivo e descritivo, utilizando análise quantitativa e qualitativa. Mulheres com diferentes diagnósticos foram avaliadas por meio de biópsia e exame de urina. Resultados: Foram selecionadas 87 mulheres, divididas em quatro grupos: grupo controle (27,6%), grupo com condiloma acuminado (21,8%), grupo com lesão intraepitelial de baixo grau (21,8%) e grupo com lesão intraepitelial de alto grau (28,7%). Os resultados mostraram que o exame de urina apresentou valor preditivo de 78,7% quando comparado ao padrão ouro, a biópsia. O grupo com lesão intraepitelial de alto grau apresentou concordância perfeita com os resultados do exame de urina. Os genótipos de HPV mais frequentemente identificados foram HPV16, seguido por HPV6, 52 e 53. Conclusão: O exame de urina mostrou-se valioso na investigação do DNA do HPV, especialmente no grupo com lesão intraepitelial de alto grau. No entanto, são necessárias mais pesquisas para ampliar o estudo, e estratégias adicionais devem ser empregadas para aumentar a adesão das mulheres.
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