Resumo
Objetivo: Analisar o perfil clínico-epidemiológico e assistencial de recém-nascidos prematuros internados em uma Unidade de Terapia Intensiva Neonatal (UTIN). Métodos: Estudo transversal, descritivo e inferencial, com abordagem quantitativa, realizado por meio da análise de 54 prontuários de recém-nascidos prematuros internados na UTIN de um hospital de referência no estado do Pará entre março e agosto de 2025. Foram analisadas variáveis clínicas e perinatais, incluindo sexo, idade gestacional, peso ao nascer, escore de Apgar, intervenções terapêuticas e desfecho clínico. Resultados: Predominou o sexo masculino (57,41%). Observou-se elevada frequência de muito baixo peso ao nascer (48,15%) e idade gestacional entre 28 e 31 semanas (48,15%). No primeiro minuto, 62,97% apresentaram Apgar<7, com melhora no quinto minuto em 77,78% dos casos. A síndrome do desconforto respiratório ocorreu em 96,30% dos neonatos. Todos os recém-nascidos necessitaram de ventilação mecânica invasiva, 77,78% receberam surfactante, 88,89% utilizaram antibióticos, 64,81% necessitaram de reanimação ao nascimento, 51,85% receberam transfusão sanguínea e 87,04% foram submetidos à fototerapia. Conclusão: Os recém-nascidos apresentaram elevada vulnerabilidade clínica e grande demanda por intervenções intensivas, evidenciando a complexidade do cuidado neonatal.
Referências
ANTUNES JLF, et al. Mortalidade por câncer bucal e de orofaringe no Brasil, de 2000 a 2013: tendências por estratos sociodemográficos. Ciência & Saúde Coletiva, 2020; 25: 3075–3086.
ANTUNES JLF, et al. Gender and racial inequalities in trends of oral cancer mortality in São Paulo, Brazil. Revista de Saúde Pública, 2013; 47(3): 470–478.
BAKKER NAM, et al. HPV-16 E6/E7 DNA tattoo vaccination using genetically optimized vaccines elicit clinical and immunological responses in patients with usual vulvar intraepithelial neoplasia (uVIN): a phase I/II clinical trial. Journal for ImmunoTherapy of Cancer, 2021; 9: e002547.
BERMAN TA, SCHILLER JT. Human papillomavirus in cervical cancer and oropharyngeal cancer: one cause, two diseases. Cancer, 2017; 123(12): 2219–2229.
BOING AF, ANTUNES JLF. Condições socioeconômicas e câncer de cabeça e pescoço: uma revisão sistemática de literatura. Ciência & Saúde Coletiva, 2011; 16(2): 615–622.
BRUNO MT, et al. Oral HPV infection in women with HPV-positive cervix is closely related to oral sex. Diagnostics, 2023; 13(12).
CAMPISI G, et al. Oral human papillomavirus infection in women with cervical HPV infection: new data from an Italian cohort and a meta-analysis of the literature. Oral Oncology, 2011; 47(4): 244–250.
CHATURVEDI AK, ZUMSTEG ZS. A snapshot of the evolving epidemiology of oropharynx cancers. Cancer, 2018; 124(14): 2893–2896.
CHRISTENSEN JT, et al. Association between oropharyngeal cancers with known HPV and p16 status and cervical intraepithelial neoplasia: a Danish population-based study. Acta Oncologica, 2019; 58(3): 267–272.
CUNHA AR, et al. Hospitalizations for oral and oropharyngeal cancer in Brazil by the SUS: impacts of the COVID-19 pandemic. Revista de Saúde Pública, 2023; 57: 3s.
DANTAS TS, et al. Influence of educational level, stage, and histological type on survival of oral cancer in a Brazilian population. Medicine, 2016; 95(3): e2314.
FONSECA EP, et al. Modelo bayesiano e análise espacial da mortalidade por câncer de boca e orofaringe em Minas Gerais, Brasil. Ciência & Saúde Coletiva, 2018; 23(1): 153–160.
KALLIALA I, et al. Incidence and mortality from cervical cancer and other malignancies after treatment of cervical intraepithelial neoplasia: a systematic review and meta-analysis of the literature. Annals of Oncology, 2020; 31(2): 213–227.
KOMBE KAJ, et al. Epidemiology and burden of human papillomavirus and related diseases, molecular pathogenesis, and vaccine evaluation. Frontiers in Public Health, 2021; 8: 552028.
LECHNER M, et al. HPV-associated oropharyngeal cancer: epidemiology, molecular biology and clinical management. Nature Reviews Clinical Oncology, 2022; 19(1): 19–32.
LOOPIK DL, et al. The relative risk of noncervical high-risk human papillomavirus-related (pre)malignancies after recurrent cervical intraepithelial neoplasia grade 3: a population-based study. International Journal of Cancer, 2019; 147(3): 897–900.
MALTA DC, et al. Evolução de indicadores do tabagismo segundo inquéritos telefônicos, 2006–2014. Cadernos de Saúde Pública, 2017; 33(supl. 3).
MENEZES FS, et al. The emerging risk of oropharyngeal and oral cavity cancer in HPV-related subsites in young people in Brazil. PLoS ONE, 2020; 15(5).
MORO JS, et al. Oral and oropharyngeal cancer: epidemiology and survival analysis. Einstein (São Paulo), 2018; 16(2).
PEREA LME, et al. Mortalidade por câncer de boca e orofaringe: efeito idade-período-coorte, Brasil, 1983–2017. Revista de Saúde Pública, 2021; 55: 72.
PEREA LME, et al. Trend of oral and pharyngeal cancer mortality in Brazil in the period of 2002 to 2013. Revista de Saúde Pública, 2018; 52.
PRETI M, et al. Risk of HPV-related extra-cervical cancers in women treated for cervical intraepithelial neoplasia. BMC Cancer, 2020; 20(1).
RATHOD S, et al. Empowering women’s health: insights into HPV vaccination and the prevention of invasive cervical cancer. Cureus, 2023; 15(11).
RODRIGUES V, et al. State-of-the-science concepts of HPV-related oropharyngeal squamous cell carcinoma: a comprehensive review. Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, 2022; 134(2): 190–205.
SOERJOMATARAM I, BRAY F. Planning for tomorrow: Global cancer incidence and the role of prevention 2020–2070. Nature Reviews Clinical Oncology, 2021; 18(10): 663–672.
SUK R, et al. Trends in risks for second primary cancers associated with index human papillomavirus–associated cancers. JAMA Network Open, 2020; 1(5): e181999.
TEWARI P, et al. Prevalence and concordance of oral HPV infections with cervical HPV infections in women referred to colposcopy with abnormal cytology. Journal of Oral Pathology and Medicine, 2021; 50(7): 692–699.
TOTA JE, et al. Evolution of the oropharynx cancer epidemic in the United States: moderation of increasing incidence in younger individuals and shift in the burden to older individuals. Journal of Clinical Oncology, 2019; 37(18): 1538–1546.
WANG M, et al. Risk of subsequent malignant neoplasms after an index potentially human papillomavirus–associated cancer. Cancer Epidemiology, 2020; 64: 101649.
WOLF J, et al. Human papillomavirus infection: epidemiology, biology, host interactions, cancer development, prevention, and therapeutics. Reviews in Medical Virology, 2024; 34(3): e2537.
