Palavras-chave
Estresse oxidativo
Glutationa
Espécies reativas de oxigênio
Avaliação nutricional
Como Citar
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Resumo
Objetivo: Analisar biomarcadores de estresse oxidativo (EO), com foco no mecanismo da glutationa, após um período de um ano nos mesmos pacientes em hemodiálise. Métodos: Estudo observacional e longitudinal realizado em uma clínica de diálise. Foram analisadas: glutationa reduzida (GSH), glutationa oxidada (GSSG), a razão GSH:GSSG e glutationa peroxidase (GPx). Para a análise estatística, foram utilizados o teste t de Student pareado, o teste de Wilcoxon, o teste do qui-quadrado e a correlação de Pearson ou Spearman. Os tamanhos do efeito foram calculados com o g de Hedges e o delta de Cliff. Para a análise retrospectiva do poder estatístico, foi utilizado o software G*Power®. P < 0,05 foi considerado estatisticamente significativo. Resultados: Dez pacientes concluíram o estudo. Após um período de um ano, observou-se aumento nos níveis de GSSG (P=0,000) e GPx (P=0,041), e diminuição nos níveis de GSH (P=0,007) e na razão GSH:GSSG (P=0,000). Correlações positivas moderadas, não significativas, foram encontradas entre o tempo em hemodiálise e os níveis de GSSG (rho = 0,4108, p=0,5), e uma correlação negativa moderada entre os níveis de GSH (rho = -0,5817, p=0,007) e a razão GSH:GSSG (rho = -0,5123, p=0,025). Conclusão: Houve aumento significativo no EO relacionado ao mecanismo da glutationa.
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