Palavras-chave
Berberina
Resistência à insulina
Fitoterapia
Como Citar
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Resumo
Objetivo: Analisar os efeitos metabólicos, hormonais e reprodutivos da berberina e de suas novas formulações no tratamento da Síndrome dos Ovários Policísticos (SOP). Métodos: Revisão integrativa da literatura, conduzida em abril de 2026, nas bases PubMed, SciELO, Scopus, Web of Science, Embase e LILACS, seguindo o protocolo PRISMA. A pergunta norteadora foi estruturada pela estratégia PICO, para selecionar estudos primários em humanos publicados entre 2016 e 2025, em inglês, português ou espanhol. Resultados: A amostra final foi composta por 4 estudos intervencionistas. A berberina promoveu melhoras consistentes na resistência à insulina, perfil lipídico e composição corporal. Hormonalmente, reduziu a testosterona livre, elevou a globulina ligadora de hormônios sexuais (SHBG) e melhorou manifestações do hiperandrogenismo. Reprodutivamente, regularizou o ciclo menstrual em até 70% das pacientes. O Fitossomo de Berberina demonstrou eficácia em doses menores com melhor tolerabilidade gastrointestinal. A berberina apresentou eficácia comparável à metformina com perfil de segurança superior. Considerações finais: A berberina configura estratégia complementar promissora no manejo da SOP, especialmente em sua formulação fitossomada; contudo, limitações metodológicas dos estudos incluídos reforçam a necessidade de ensaios clínicos randomizados, multicêntricos e com maior rigor para consolidar sua aplicação clínica.
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