Clinical description of a case of Cryptococyse associated with B-cell Non-Hodgkin Lymphoma

Abstract

Objective: To demonstrate an approach of a patient who was presumed immunocompetent at the beginning of the study, but with a diagnosis of non-Hodgkin type B lymphoma made during treatment of cryptococcosis. Case details: The case described is a 48-year-old male patient diagnosed with neurocryptococcosis, who presented major symptoms of severe headache, hyporexia, mental confusion, deterration and febrile peaks. On physical examination, signs of meninginism associated with bilateral inguinal lymphadenomegaly and grade II splenomegaly were observed, without further alterations. Laboratory and imaging tests were requested before the clinic, which complemented and assisted for the diagnostic conclusion of neurocryptococcosis. Subsequently, treatment was instituted with ampothericin B and fluconazole, both intravenous. Final considerations: Because it is a disease that affects more immunodeficient individuals, especially HIV positive, it also affects immunocompetent individuals, reaching the lungs ranging from insignificant symptoms to prolonged respiratory conditions. The patient in question presented good clinical evolution to treatment, and continues under outpatient follow-up. Once it is a neglected pathology, information would be needed for more specialized studies, leading to early diagnosis and, consequently, to an adequate and effective conduct.